DI-1859 - ≥99% , CAS No.2247061-09-0
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SKU
D649174
DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage.
Form:Solid
Plus d’information
| CAS | 2247061-09-0 |
|---|---|
| Spécifications et pureté | ≥99% |
| Conditions de stockage de stockage | Store at -20°C |
| Expédié en | Ice chest + Ice pads |
| Product Description | DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage. Form:Solid |
| Solubilité | DMSO : 100 mg/mL (179.93 mM; ultrasonic and warming and heat to 60°C) |
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