Divalproex Sodium - 10mM in DMSO , Succinate semialdehyde dehydrogenase inhibitor, CAS No.76584-70-8, Succinate semialdehyde dehydrogenase inhibitor

CAS: 76584-70-8 Cat. No.: D408831 Formule: C₁₆H₃₂NaO₄ Poids moléculaire: 311.42 Numéro CE: 630-325-9

GRADE & PURITY 10mM in DMSO

Synonyms

2-​propyl-pentanoic acid, sodium salt (2:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Divalproex Sodium Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
In vitro

Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonymes

2-​propyl-pentanoic acid, sodium salt (2:1)

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Mécanisme d'action

Succinate semialdehyde dehydrogenase inhibitor

Noms et identifiants

• Isomères SMILES: CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
• Poids moléculaire: 311.42
• Reaxy-Rn: 8462424
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8462424&ln=

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro Water: 100 mg/mL (46.3 mM)