DL-Carnitine - 10mM in DMSO , CAS No.461-06-3

CAS: 461-06-3 Cat. No.: D424086 Formule: C₇H₁₅NO₃ Poids moléculaire: 161.2

GRADE & PURITY 10mM in DMSO

Synonyms

DL-Carnitine|Carnitine|406-76-8|L(-)-Carnitine|461-06-3|Carnitine DL-form|Carnitine [INN]|Carnitina|3-hydroxy-4-(trimethylammonio)butanoate|3-hydroxy-4-(trimethylazaniumyl)butanoate|Carnitine chloride|D,L-carnitine|Levocarnitine;Vitamin B(T)|S7UI8SM58A|Ca

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulatesfatty acid transportin the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine causes symptoms of myasthenia and cardiac arrhythmias.

Specifications

Synonymes

DL-Carnitine | Carnitine | 406-76-8 | L(-)-Carnitine | 461-06-3 | Carnitine DL-form | Carnitine [INN] | Carnitina | 3-hydroxy-4-(trimethylammonio)butanoate | 3-hydroxy-4-(trimethylazaniumyl)butanoate | Carnitine chloride | D,L-carnitine | Levocarnitine;Vitamin B(T) | S7UI8SM58A | Ca

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulates fatty acid transport in the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine ca

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Pubchem Sid: 528764179
• Sourires canoniques: C[N+](C)(C)CC(CC(=O)[O-])O
• IUPAC Name: 3-hydroxy-4-(trimethylazaniumyl)butanoate
• InChIKey: PHIQHXFUZVPYII-UHFFFAOYSA-N
• INCHI: 1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3
• Isomères SMILES: C[N+](C)(C)CC(CC(=O)[O-])O
• CAS alternatif: 406-76-8
• Poids moléculaire: 161.2
• Reaxy-Rn: 1866665
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1866665&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Quaternary ammonium salts

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Quaternary ammonium salts
• Intermediate Tree Nodes: Not available
• Direct Parent: Carnitines
• Alternative Parents: Short-chain hydroxy acids and derivatives Beta hydroxy acids and derivatives Fatty acids and conjugates Tetraalkylammonium salts Secondary alcohols Carboxylic acid salts 1,2-aminoalcohols Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic zwitterions Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Carnitine - Beta-hydroxy acid - Short-chain hydroxy acid - Fatty acid - Hydroxy acid - Tetraalkylammonium salt - 1,2-aminoalcohol - Carboxylic acid salt - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxygen compound - Organooxygen compound - Organic zwitterion - Organic salt - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organopnictogen compound - Amine - Alcohol - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as carnitines. These are organic compounds containing the quaternary ammonium compound carnitine.
• External Descriptors: a D,L-carnitine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

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ABCB11 Tchem Bile salt export pump (2311 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (580 Activities)

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SLC22A9 Tbio Solute carrier family 22 member 9 (14 Activities)

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SLC22A16 Tbio Solute carrier family 22 member 16 (4 Activities)

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Cibles associées (non humaines)

Slc25a20 Carnitine/acylcarnitine translocase (26 Activities)

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Slc22a5 Solute carrier family 22 member 5 (44 Activities)

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Slc22a4 Solute carrier family 22 member 4 (11 Activities)

Discover Target: Slc22a4

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Slc22a21 Solute carrier family 22 member 21 (8 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Poids moléculaire: 161.200 g/mol
• XLogP3: -0.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 161.105 Da
• Monoisotopic Mass: 161.105 Da
• Topological Polar Surface Area: 60.400 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 134.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Références

1. Weili Li, Haiyang Li, Lujuan Zheng, Jing Xia, Xiaoxuan Yang, Shuhan Men, Ye Yuan, Yuying Fan.  (2022)  Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy.  Food & Function,  14  (2): (1024-1036).  [PMID:36562271] [10.1039/D2FO02026B]