DL-Mevalonolactone - ≥98% , CAS No.674-26-0

CAS: 674-26-0 Cat. No.: D304342 Formule: C₆H₁₀O₃ Poids moléculaire: 130.14 Numéro CE: 211-615-0

GRADE & PURITY ≥98%

Synonyms

LMFA07040003 | 1RJ06DC41B | MEVALONOLACTONE, DL- | Mevalonic acid .delta.-lactone | 009D7F12-69C6-4BBF-A66D-12BA84648C72 | AS-65830 | HMS2097E22 | NCGC00179453-01 | .beta.-Hydroxy-.beta.-methyl-.delta.-valerolactone | 2H-PYRAN-2-ONE, TETRAHYDRO-4-HYDROXY-

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation. 

Application

(±)-Mevalonolactone is used to:

• study the effect of statin on the prenylation of Ras and Rho GTPases

• analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes

• study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells) 

Specifications

Synonymes

LMFA07040003 | 1RJ06DC41B | MEVALONOLACTONE, DL- | Mevalonic acid .delta.-lactone | 009D7F12-69C6-4BBF-A66D-12BA84648C72 | AS-65830 | HMS2097E22 | NCGC00179453-01 | .beta.-Hydroxy-.beta.-methyl-.delta.-valerolactone | 2H-PYRAN-2-ONE, TETRAHYDRO-4-HYDROXY-

Spécifications et pureté

≥98%

Conditions de stockage de stockage

Store at -20°C,Argon charged

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Noms et identifiants

• Pubchem Sid: 508810493
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/508810493
• Sourires canoniques: CC1(CCOC(=O)C1)O
• IUPAC Name: 4-hydroxy-4-methyloxan-2-one
• InChIKey: JYVXNLLUYHCIIH-UHFFFAOYSA-N
• INCHI: 1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3
• Isomères SMILES: CC1(CCOC(=O)C1)O
• Poids moléculaire: 130.14
• Reaxy-Rn: 80960
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=80960&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Lactones
      • Subclass Delta valerolactones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Lactones
• Subclass: Delta valerolactones
• Intermediate Tree Nodes: Not available
• Direct Parent: Delta valerolactones
• Alternative Parents: Oxanes Tertiary alcohols Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Delta_valerolactone - Delta valerolactone - Oxane - Tertiary alcohol - Carboxylic acid ester - Oxacycle - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
• External Descriptors: Lactones

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mécanismes d'action

Propriétés chimiques et physiques

• Sensibilité: Moisture & heat sensitive
• Indice de réfraction: 1.48
• Point d'éclair (°F): 235.4 °F
• Point d'éclair (°C): 113 °C
• Point d'ébullition (°C): 150 °C/5 mmHg
• Point de fusion (°C): 28 °C
• Poids moléculaire: 130.139 g/mol
• XLogP3: -0.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 130.063 Da
• Monoisotopic Mass: 130.063 Da
• Topological Polar Surface Area: 46.500 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 132.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1