DOTAP Transfection Reagent - 1 mg/ml in MES-buffered saline , CAS No.144189-73-1

CAS: 144189-73-1 Cat. No.: D353304 Formule: C₄₃H₈₃NO₈S Poids moléculaire: 774.19

GRADE & PURITY 1 mg/ml in MES-buffered saline

Synonyms

DOTAP | 18:1 TAP (DOTAP, MS Salt), 1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt), chloroform | N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate | DOTAP Liposomal Transfection Reagent, N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-t

Storage

Store at 2-8°C

Shipped In

Wet ice

Vue d’ensemble

DOTAP Transfection Reagent is a liposomal formulation of the cationic lipid DOTAP. DOTAP Transfection Reagent is used not only for DNA and RNA transfection, but yeast artificial chromosomes (YAC) as well, with or without serum. This transfection via DOTAP Transfection Reagent is between eukaryotic cells in iehter transient or stable gene expression. DOTAP Transfection Reagent is also suitable for other negatively charged molecules, including oligonucleotidees and glutamic acid.

Specifications

Synonymes

DOTAP | 18:1 TAP (DOTAP, MS Salt), 1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt), chloroform | N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate | DOTAP Liposomal Transfection Reagent, N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-t

Spécifications et pureté

1 mg/ml in MES-buffered saline

Conditions de stockage de stockage

Store at 2-8°C

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Pubchem Sid: 528764222
• Sourires canoniques: CCCCCCCCC=CCCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC.COS(=O)(=O)[O-]
• IUPAC Name: 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;methyl sulfate
• InChIKey: RSMRWWHFJMENJH-LQDDAWAPSA-M
• INCHI: 1S/C42H80NO4.CH4O4S/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;1-5-6(2,3)4/h20-23,40H,6-19,24-39H2,1-5H3;1H3,(H,2,3,4)/q+1;/p-1/b22-20-,23-21-
• Isomères SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.COS(=O)(=O)[O-]
• WGK Allemagne: 3
• Poids moléculaire: 774.19
• Reaxy-Rn: 34197390
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34197390&ln=

Propriétés chimiques et physiques

• Point d'ébullition (°C): 100 °C
• Point de fusion (°C): -5 °C
• Poids moléculaire: 774.200 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 37
• Exact Mass: 773.584 Da
• Monoisotopic Mass: 773.584 Da
• Topological Polar Surface Area: 127.000 Ų
• Heavy Atom Count: 53
• Formal Charge: 0
• Complexity: 845.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

XLogP3

Références

1. Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu.  (2022)  A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma.  Biomaterials Science,  10  (23): (6791-6803).  [PMID:36314541] [10.1039/D2BM01145J]

2. Binke Wang, Xinyu Qi, Ruping Yang, Xu Xu, Shiyao Li, Chunli Zhang, Haitao Yu.  (2025)  Cubosome-based co-delivery of doxorubicin and polydatin for targeted cancer therapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.168855]