DRAK2-IN-1 - ≥99% , CAS No.871837-60-4

CAS: 871837-60-4 Cat. No.: D650626 Formule: C₂₁H₂₀N₄O₃ Poids moléculaire: 376.41 PubChem CID: 136175114

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

DRAK2-IN-1, compound 16, is a potent, selective and ATP-competitive DRAK2 inhibitor with IC 50 and K i values of 3 nM and 0.26 nM, respectively.DRAK2-IN-1 also has inbitory effect on DRAK1 ( IC 50 =51 nM)

Form:Solid

IC50& Target:IC50: 3 nM (DRAK2),51 nM (DRAK1),1.8 μM (DRPK2),2.3 μM (DRAK2),1.8 μM (DRPK3)

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

DRAK2-IN-1, compound 16, is a potent, selective and ATP-competitive DRAK2 inhibitor with IC 50 and K i values of 3 nM and 0.26 nM, respectively.\nDRAK2-IN-1 also has inbitory effect on DRAK1 ( IC 50 =51 nM).

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

• Sourires canoniques: CCCCC(=O)NC1=CC2=C(C=C1)NC(=C2C3=C(C4=CC=CC=C4N3)N=O)O
• IUPAC Name: N-[2-hydroxy-3-(3-nitroso-1H-indol-2-yl)-1H-indol-5-yl]pentanamide
• InChIKey: ZFZLSKZDOULLMO-UHFFFAOYSA-N
• INCHI: 1S/C21H20N4O3/c1-2-3-8-17(26)22-12-9-10-16-14(11-12)18(21(27)24-16)20-19(25-28)13-6-4-5-7-15(13)23-20/h4-7,9-11,23-24,27H,2-3,8H2,1H3,(H,22,26)
• Isomères SMILES: CCCCC(=O)NC1=CC2=C(C=C1)NC(=C2C3=C(C4=CC=CC=C4N3)N=O)O
• PubChem CID: 136175114
• Poids moléculaire: 376.41

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Hydroxyindoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Hydroxyindoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydroxyindoles
• Alternative Parents: Indoles N-arylamides Substituted pyrroles Fatty amides Benzenoids Heteroaromatic compounds Secondary carboxylic acid amides Propargyl-type 1,3-dipolar organic compounds C-nitroso compounds Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Hydroxyindole - Indole - N-arylamide - Fatty acyl - Benzenoid - Substituted pyrrole - Fatty amide - Heteroaromatic compound - Pyrrole - Secondary carboxylic acid amide - Carboxamide group - Organic nitroso compound - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid derivative - C-nitroso compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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DAPK3 Tchem Death-associated protein kinase 3 (2108 Activities)

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DAPK2 Tchem Death-associated protein kinase 2 (740 Activities)

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DAPK1 Tchem Death-associated protein kinase 1 (1664 Activities)

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STK17B Tchem Serine/threonine-protein kinase 17B (773 Activities)

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STK17A Tchem Serine/threonine-protein kinase 17A (1791 Activities)

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ALK Tclin ALK tyrosine kinase receptor (7132 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO : 100 mg/mL (265.67 mM; Need ultrasonic)