DRF-1042 - 10mM in DMSO , CAS No.200619-13-2

CAS: 200619-13-2 Cat. No.: D655919 Formule: C₂₂H₂₀N₂O₆ Poids moléculaire: 408.40 PubChem CID: 23631031

QUALITÉ & PURETÉ 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I . DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype

In Vitro

DRF-1042 demonstrates superior lactone stability and good in vitro anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In clonogenic assay against murine, canine and human bone marrow cells, DRF-1042 treatment shows less mylosupression that supports the possibility of protracted dose schedule in both experimental and clinical studies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:DNA topoisomerase I

Spécifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I . DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype.

Conditions de stockage de stockage

Argon charged,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

Isomères SMILES

CC[C@@]1(C2=C(COC1=O)C(=O)N3C(C4=CC5=CC=CC=C5N=C4C3=C2)OCCO)O

CAS alternatif

200619-13-2

PubChem CID

23631031

Termes d'entrée MeSH

5-(2'-hydroxyethoxy)-20(S)-camptothecin;DRF-1042;DRF1042

Poids moléculaire

408.40