Duloxetine HCl - 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.136434-34-9, Norepinephrine transporter inhibitor

CAS: 136434-34-9 Cat. No.: D407972 Molecular Weight: 333.88 EC Number: 603-962-5

GRADE & PURITY 10mM in DMSO

Synonyms

LY-248686 HCl | (γS)​-N-​methyl-​γ-​(1-​naphthalenyloxy)​-2-​thiophenepropanamine, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Duloxetine HCl Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with K i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
In vitro

In vivo

Cell Data

cell lines：CAL-62 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

LY-248686 HCl | (γS)​-N-​methyl-​γ-​(1-​naphthalenyloxy)​-2-​thiophenepropanamine, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Norepinephrine transporter inhibitor

Names and Identifiers

• Isomeric SMILES: CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
• WGK Germany: 3
• RTECS: XN0258000
• Alternate CAS: 116817-13-1
• Molecular Weight: 333.88
• Reaxy-Rn: 13592284
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13592284&ln=

Chemical and Physical Properties

• Refractive Index: 122° (C=1,MeOH)
• Specific Rotation[α]: 122° (C=1,MeOH)
• Melt Point(°C): 164℃

References

1. Weijun Zhou, Wenyun Zhou, Yonghao Bi, Zibin Zhou, Zhigao Zhou, Shaozhe Chen, Gang Xie, Zhen Lian, Guixin Yuan, Guanfeng Yao.  (2023)  Antidepressant duloxetine hydrochloride protects against ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:37913736] [10.1016/j.biopha.2023.115810]

2. Jingjing Chen, Peipei Li, Yixiu Han, Yuchen Li, Yingxiang Du.  (2023)  Highly photoluminescent nitrogen-doped carbon quantum dots as a green fluorescence probe for determination of myricetin.  FOOD CHEMISTRY,      [PMID:36933427] [10.1016/j.foodchem.2023.135920]

3. Xiujuan Chen, Chen Liang, Lijun Cui, Jian Le, Zheyuan Qian, Runsheng Zhang, Zhanying Hong, Yifeng Chai.  (2018)  A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study.  JOURNAL OF FOOD AND DRUG ANALYSIS,      [PMID:30648587] [10.1016/j.jfda.2018.07.003]

4. Rikun Cui, Zhenzhao Wang, Linna Li, Lili Liu, Zhen Li, Xingtong Liu, Tingting Chen, Ayesha Rauf, Xiaofeng Kang, Yanli Guo.  (2024)  Bionic nanopore recognition receptors for single-molecule enantioselectivity studies of chiral drugs.  ANALYTICA CHIMICA ACTA,      [PMID:39067929] [10.1016/j.aca.2024.342960]