DX600 TFA - ≥99% , CAS No.D414451

CAS: D414451 Cat. No.: D414451 Formule: C₁₄₁H₁₈₅N₃₅O₄₀S₂ Poids moléculaire: 3074.32

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

DX600 DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE.

Targets

ACE2

In vitro

DX600 is an ACE2 specific inhibitor that does not cross-react with ACE. Three human cell lines (Calu-3, Caco-2, Huh-7) are evaluated for the cell surface expression of ACE2 by flow cytometry and Western blot. Subsequently, whole cell lysates, cell culture supernatant, and live cells are evaluated in the assay. Calu-3 has elevated levels of ACE2 compared to Caco-2 or Huh-7. Calu-3 also demonstrates elevated ACE2 enzymatic activity in all three sources and can be inhibited by DX600.

In vivo

Mouse ACE2-driven Ang-(1-7) formation from Ang II is blocked by MLN-4760 but not by either linear or cyclic DX600. DX600 only blocks human ACE2 activity.

Cell Research(from reference)

Cell lines：Three human cell lines (Calu-3, Caco-2, Huh-7) 

Concentrations：10 μM 

Incubation Time：1 h 

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

• Poids moléculaire: 3074.32

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro Water: 100 mg/mL (32.52 mM)