Edasalonexent - 10mM in DMSO , Nuclear factor NF-kappa-B complex inhibitor, CAS No.1204317-86-1, Nuclear factor NF-kappa-B complex inhibitor

CAS: 1204317-86-1 Cat. No.: E654643 Molecular Weight: 490.68 PubChem CID: 44626120

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

In Vitro

Edasalonexent is an orally administered small molecule in which salicylic acid and docosahexaenoic acid (DHA) are covalently conjugated through an ethylenediamine linker and that is designed to synergistically leverage the ability of both of these compounds to inhibit NF-κB. Edasalonexent significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever duchenne muscular dystrophy (DMD) model. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The treatment of mdx mice with Edasalonexent for 20 weeks results in reduced susceptibility of the extensor digitorum longus muscle to eccentric contraction-induced injury . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NF-κB

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Nuclear factor NF-kappa-B complex inhibitor

Product Properties

• ALogP: 7.1

Names and Identifiers

• Isomeric SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)NCCNC(=O)C1=CC=CC=C1O
• Alternate CAS: 1204317-86-1
• PubChem CID: 44626120
• MeSH Entry Terms: CAT-1004;edasalonexent
• Molecular Weight: 490.68