(-)-Epicatechin - Moligand™, ≥97%(HPLC) , CAS No.490-46-0

Name: (-)-Epicatechin - Moligand™, ≥97%(HPLC) , CAS No.490-46-0
Brand: Aladdin Scientific
SKU: E130023
Availability: InStock

CAS: 490-46-0 Cat. No.: E130023 Formule: C₁₅H₁₄O₆ Poids moléculaire: 290.27 Beilstein Registry Number: 92760 Numéro CE: 207-710-1

143 Citations COA

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(-)-Epicatechin - Moligand™, ≥97%(HPLC) CAS No(490-46-0) E130023 by Aladdin Scientific

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DISPONIBLE À COMMANDE

QUALITÉ & PURETÉ Moligand™ ? ≥97%(HPLC)

Synonyms

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Fiche de spécifications

Vue d’ensemble Spécifications Noms et identifiants Documentation Données avancées Taxonomic Classification Structure 3D Cibles associées (humaines) Cibles associées (non humaines) Mécanismes d'action Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques FAQ et articles Citations of This Product Calculateurs de solution Avis

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Pourquoi cette qualité

Moligand™, ≥97%(HPLC) Moligand™ pour les flux de travail chromatographiques et analytiques sensibles nécessitant une interférence de ligne de base minimale.

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Stockage & expédition

Store at 2-8°C,Argon charged Expédition Wet ice. Consultez le COA spécifique au lot pour les spécifications exactes.

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SDS, COA, fiche technique et fiche de spécifications disponibles au téléchargement. COA spécifique au lot accessible via la recherche par numéro de lot.

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Preuve documentaire

Cité dans 143 publications à comité de lecture couvrant la chromatographie, la synthèse organique et les réactions de couplage croisé.

Vue d’ensemble

Epicatechin is a flavanol. Cacao products are rich in epicatechin. Epicatechin enhances the skeletal muscle structure in heart failure patients and minimises the cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth.
Antioxidant found in chocolate.

Product description：

(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

Application：

(−)-Epicatechin (EC) has been used:

as an antioxidant to downregulate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase and improve insulin sensitivity in in vivo (high fat-fed mice) and in vitro (HepG2 cells) studies

to study its effect on blood pressure, nitric oxide synthase (NOS) activity and anxiety-like behavior on borderline hypertensive rat (BHR) models

to test its effect on neuronal survival in the hippocampus of middle-aged rats on swimming training, under oxidative stress

to study its antioxidant activity in dark chocolate

as a characteristic compound in polyphenols analysis

Spécifications

Synonymes

Spécifications et pureté

Moligand™, ≥97%(HPLC)

Mécanismes biochimiques et physiologiques

Epicatechin enhances the skeletal muscle structure in heart failure patients and minimizes cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth

Source

Tea

Conditions de stockage de stockage

Store at 2-8°C,Argon charged

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Pureté

≥97%(HPLC)

Noms et identifiants

Pubchem Sid

488184683

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488184683

Sourires canoniques

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

IUPAC Name

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

InChIKey

PFTAWBLQPZVEMU-UKRRQHHQSA-N

INCHI

1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1

Isomères SMILES

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

WGK Allemagne

RTECS

KB3745000

CAS alternatif

490-46-0,17334-50-8

Termes d'entrée MeSH

(+)-Catechin;(+)-Cyanidanol;(+)-Cyanidanol-3;(-)-Epicatechin;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol;2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-;3,3',4',5,7-Flavanpentol;Catechin;Catechinic Acid;Catechuic Acid;

Poids moléculaire

290.27

Beilstein

92760

Reaxy-Rn

6069926

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6069926&ln=

Documentation

📋 Fiche de données de sécurité (FDS)

Document complet couvrant les dangers, la manipulation, le stockage et la conformité réglementaire.

<<<<<<< HEAD Télécharger la SDS → ======= Télécharger la SDS → >>>>>>> release248-p3

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Résumé de référence rapide des spécifications et applications du produit.

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Attributs de qualité complets et critères d'acceptation pour cette qualité.

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Données avancées

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Classe Flavonoids
    - Subclass Flavans
      - Level5 Flavan-3-ols
        Level6 Catechins

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Classe	Flavonoids
Subclass	Flavans
Intermediate Tree Nodes	Flavan-3-ols
Direct Parent	Catechins
Alternative Parents	7-hydroxyflavonoids 5-hydroxyflavonoids 4'-hydroxyflavonoids 3-hydroxyflavonoids 3'-hydroxyflavonoids 1-benzopyrans Catechols Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Secondary alcohols Polyols Oxacyclic compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Catechin - 3'-hydroxyflavonoid - 3-hydroxyflavonoid - 4'-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Chromane - Benzopyran - 1-benzopyran - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - Benzenoid - Monocyclic benzene moiety - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Polyol - Ether - Organic oxygen compound - Alcohol - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as catechins. These are compounds containing a catechin moiety, which is a 3,4-dihydro-2-chromene-3,5.7-tiol.
External Descriptors	Flavans, Flavanols and Leucoanthocyanidins
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Structure 3D

Cibles associées (humaines)

SNCA Tchem Alpha-synuclein (1 Activities)

Discover Target: SNCA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (1 Activities)

Discover Target: ALPL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DHFR Tclin Dihydrofolate reductase (3072 Activities)

Discover Target: DHFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

Discover Target: PTGS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

XDH Tclin Xanthine dehydrogenase (1038 Activities)

Discover Target: XDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKR1B1 Tclin Aldose reductase (1404 Activities)

Discover Target: AKR1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLA2G7 Tchem LDL-associated phospholipase A2 (1338 Activities)

Discover Target: PLA2G7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

Discover Target: POLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APP Tclin Amyloid-beta A4 protein (8510 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALB Tchem Serum albumin (2651 Activities)

Discover Target: ALB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AMY1A Salivary alpha-amylase (100 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MET Tclin Hepatocyte growth factor receptor (10718 Activities)

Discover Target: MET

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)

Discover Target: NFKB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FASN Tchem Fatty acid synthase (3390 Activities)

Discover Target: FASN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NOS3 Tchem Nitric-oxide synthase, endothelial (1452 Activities)

Discover Target: NOS3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALPG Tchem Alkaline phosphatase placental-like (1197 Activities)

Discover Target: ALPG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGD Tchem 6-phosphogluconate dehydrogenase (58 Activities)

Discover Target: PGD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SI Tchem Sucrase-isomaltase (84 Activities)

Discover Target: SI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BACE1 Tchem Beta-secretase 1 (15641 Activities)

Discover Target: BACE1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DLD-1 (17511 Activities)

Lot Number	Certificate Type	Date	Article
J2610405	Certificate of Analysis	Sep 21, 2026	E130023
J2610404	Certificate of Analysis	Sep 21, 2026	E130023
J2610403	Certificate of Analysis	Sep 21, 2026	E130023
J2610346	Certificate of Analysis	Sep 21, 2026	E130023
J2610345	Certificate of Analysis	Sep 21, 2026	E130023
K2203379	Certificate of Analysis	Jul 30, 2026	E130023
D2622424	Certificate of Analysis	Mar 09, 2026	E130023
D2622395	Certificate of Analysis	Mar 09, 2026	E130023
D2622392	Certificate of Analysis	Mar 09, 2026	E130023
I2602100	Certificate of Analysis	Mar 09, 2026	E130023
I2516248	Certificate of Analysis	Jul 19, 2025	E130023
I2516246	Certificate of Analysis	Jul 19, 2025	E130023
I2516241	Certificate of Analysis	Jul 19, 2025	E130023
I2516249	Certificate of Analysis	Jul 19, 2025	E130023
I2516250	Certificate of Analysis	Jul 19, 2025	E130023
I2516251	Certificate of Analysis	Jul 19, 2025	E130023
C2605142	Certificate of Analysis	Jul 19, 2025	E130023
E2507168	Certificate of Analysis	Apr 21, 2025	E130023
E2507169	Certificate of Analysis	Apr 21, 2025	E130023
E2507170	Certificate of Analysis	Apr 21, 2025	E130023
E2507171	Certificate of Analysis	Apr 21, 2025	E130023
E2507172	Certificate of Analysis	Apr 21, 2025	E130023
J2425451	Certificate of Analysis	Sep 23, 2024	E130023
J2425452	Certificate of Analysis	Sep 23, 2024	E130023
J2425453	Certificate of Analysis	Sep 23, 2024	E130023
J2425454	Certificate of Analysis	Sep 23, 2024	E130023
J2412077	Certificate of Analysis	Mar 18, 2024	E130023
C2430071	Certificate of Analysis	Mar 18, 2024	E130023
C2430072	Certificate of Analysis	Mar 18, 2024	E130023
C2430073	Certificate of Analysis	Mar 18, 2024	E130023
C2430074	Certificate of Analysis	Mar 18, 2024	E130023
C2430075	Certificate of Analysis	Mar 18, 2024	E130023
L2327055	Certificate of Analysis	Nov 26, 2022	E130023
D2314453	Certificate of Analysis	Nov 26, 2022	E130023
L2315046	Certificate of Analysis	Nov 26, 2022	E130023
D23131134	Certificate of Analysis	Nov 26, 2022	E130023
D23131165	Certificate of Analysis	Nov 26, 2022	E130023
D23131190	Certificate of Analysis	Nov 26, 2022	E130023
D23131208	Certificate of Analysis	Nov 26, 2022	E130023
D2314022	Certificate of Analysis	Nov 26, 2022	E130023
D2314023	Certificate of Analysis	Nov 26, 2022	E130023
D2314128	Certificate of Analysis	Nov 26, 2022	E130023
D2314142	Certificate of Analysis	Nov 26, 2022	E130023
D2314143	Certificate of Analysis	Nov 26, 2022	E130023
K2203380	Certificate of Analysis	Nov 12, 2022	E130023
K2203382	Certificate of Analysis	Nov 12, 2022	E130023
K2203383	Certificate of Analysis	Nov 12, 2022	E130023
K2203384	Certificate of Analysis	Nov 12, 2022	E130023
K2203381	Certificate of Analysis	Oct 26, 2022	E130023
C2215299	Certificate of Analysis	Mar 19, 2022	E130023

Solubilité	Soluble in acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly)., Soluble in acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly).,
Sensibilité	heat & air sensitive
Rotation spécifique [α]	-62° (C=0.1,MeOH)
Point de fusion (°C)	240°C
Poids moléculaire	290.270 g/mol
XLogP3	0.400
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Exact Mass	290.079 Da
Monoisotopic Mass	290.079 Da
Topological Polar Surface Area	110.000 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	364.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

(-)-Epicatechin - Moligand™, ≥97%(HPLC) , CAS No.490-46-0

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