EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains.
In Vitro
The hmT-derived phosphopeptide, pY324, which has the sequence EPQpYEEIPIYL, shows the highest affinity binding to GST fusion proteins of the Lck SH2 domain (5-fold higher than Lck’s affinity-for the Lck tail phosphopeptide) and the Src SH2 domain (44-fold higher than Src’s affinity for the Src tail phosphopeptide). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic Polymers |
| Classe | Polypeptides |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Polypeptides |
| Alternative Parents | Peptides Tyrosine and derivatives Phenylalanine and derivatives Glutamine and derivatives Glutamic acid and derivatives Isoleucine and derivatives Leucine and derivatives Tetracarboxylic acids and derivatives N-acyl-L-alpha-amino acids Proline and derivatives Alpha amino acid amides Phenyl phosphates Amphetamines and derivatives N-acylpyrrolidines Pyrrolidinecarboxamides Phenoxy compounds 1-hydroxy-2-unsubstituted benzenoids Hydroxy fatty acids Amino fatty acids N-acyl amines Tertiary carboxylic acid amides Primary carboxylic acid amides Amino acids Secondary carboxylic acid amides Carboxylic acids Azacyclic compounds Monoalkylamines Carbonyl compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Polypeptide - Alpha peptide - Tyrosine or derivatives - Phenylalanine or derivatives - Glutamic acid or derivatives - Glutamine or derivatives - Isoleucine or derivatives - Leucine or derivatives - Tetracarboxylic acid or derivatives - N-acyl-l-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Proline or derivatives - N-acyl-alpha-amino acid - Alpha-amino acid amide - Phenyl phosphate - Alpha-amino acid or derivatives - Aryl phosphate - Aryl phosphomonoester - Amphetamine or derivatives - N-substituted-alpha-amino acid - Phenoxy compound - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Amino fatty acid - Hydroxy fatty acid - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Fatty acyl - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Organic phosphoric acid derivative - Phosphoric acid ester - Tertiary carboxylic acid amide - Pyrrolidine - Primary carboxylic acid amide - Amino acid - Carboxamide group - Amino acid or derivatives - Secondary carboxylic acid amide - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Azacycle - Organic oxide - Carbonyl group - Amine - Organooxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Organonitrogen compound - Primary amine - Organic oxygen compound - Primary aliphatic amine - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues. |
| External Descriptors | Not available |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Solubilité | H2O : 2 mg/mL (1.36 mM; ultrasonic and adjust pH to 2 with HCl) |
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