Moligand™, 10 mM in Water Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt , which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity .
| Isomeric SMILES | C[N+](C)(C)[C@@H](CC1=CNC(=S)N1)C(=O)[O-] |
|---|---|
| WGK Germany | 3 |
| Molecular Weight | 229.30 |
| Reaxy-Rn | 3910838 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3910838&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 255 - 259 °C |
|---|
| 1. Jiaxin Peng, Jing Chen, Mengran Wu, Tao He, Xiaojuan Guo, Qiangguo Ao, Ling Chen. (2025) Proteomic analysis reveals the potential mechanism of ergothioneine in preventing acute kidney injury to chronic kidney disease transition. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, [PMID:40633826] [10.1016/j.abb.2025.110534] |
| 2. Yanju Gao, Bo Zhou, Han Zhang, Lin Chen, Xiaohong Wang, Hongbing Chen, Lin Zhou. (2022) l-Ergothioneine Exhibits Protective Effects against Dextran Sulfate Sodium-Induced Colitis in Mice. ACS Omega, [PMID:35785312] [10.1021/acsomega.2c01350] |
| 3. Qingquan Zeng, Mengru Bai, Cui Li, Shuanghui Lu, Zhiyuan Ma, Yunchun Zhao, Hui Zhou, Huidi Jiang, Dongli Sun, Caihong Zheng. (2019) Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, [PMID:31160284] [10.1128/AAC.00199-19] |
| 4. Ae Eun Seok, Jiyeong Lee, You-Rim Lee, Yoo-Jin Lee, Hyo-Jin Kim, Chunhwa Ihm, Ho Joong Sung, Sung Hee Hyun, Hee-Gyoo Kang. (2018) Estimation of Age of Bloodstains by Mass-Spectrometry: A Metabolomic Approach. ANALYTICAL CHEMISTRY, [PMID:30350957] [10.1021/acs.analchem.8b01367] |
| 5. Chaoqun Tang, Lu Zhang, Junyi Wang, Congjia Zou, Yalin Zhang, Jifeng Yuan. (2024) Engineering Saccharomyces boulardii for Probiotic Supplementation of l-Ergothioneine. Biotechnology Journal, 19 (11): (e202400527). [PMID:39562168] [10.1002/biot.202400527] |
| 6. Shun Zhong, Yao Yao Qi, Yuan Yuan, Li Lian, Zeyuan Deng, Feng Pan, Junfu Zhou, Zhiyu Wang, Hongyan Li. (2024) Ganoderma lucidum spore powder after oil extraction alleviates microbiota dysbiosis to improve the intestinal barrier function in mice. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, [PMID:39243161] [10.1002/jsfa.13852] |
| 7. Yu-Zhen Li, Qi Wang, Cheng Cheng, Chao Chen, Feng-Li Zhang, Yue Zou, Jun Li, Xin-Qing Zhao. (2025) Genome mining of an endophytic natural yeast isolate Rhodotorula sp. Y090 and production of the antioxidant ergothioneine. JOURNAL OF BIOTECHNOLOGY, [PMID:40169100] [10.1016/j.jbiotec.2025.03.019] |
| 8. Bohan Zhang, Qingling Nie, Xin Yan, Qiaojun Jiang, Junjie Ren, Peipei Xu, Dechan Lu, Ruiyun You, Lizhi Li, Yudong Lu. (2024) Machine learning-based SERS label-free detection of plasma and exosome binding in early-stage lung cancer. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.111306] |
| 9. Mingyang Chen, Yaodong Yi, Binxin Chen, Hengbin Zhang, Minlei Dong, Luexiang Yuan, Hui Zhou, Huidi Jiang, Zhiyuan Ma. (2024) Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice. TOXICOLOGY, [PMID:38364893] [10.1016/j.tox.2024.153757] |
| 10. Hongyu Jiang, Haonan Gong, Wang Li, Yingxi Chen, Yiwei Dai, Yujiao Zhang, Beiwei Zhu, Sufang Zhang. (2025) Preparation and characterization of edible films based on sodium alginate cross-linked lactoferrin-ergothioneine compounds: Unraveling molecular interactions. Food Bioscience, [PMID:] [10.1016/j.fbio.2025.106101] |
| 11. Yamiao Li, Jingxin Rao, Zhentao Jiang, Xinyi Zhang, Qiang Zhu, Caokai Zhu, Wenli Yu, Xin Dong, Shanshan Gao, Wenchi Zhang, Liang Lin, Mingyue Zheng, Rongzhen Zhang. (2025) AI-driven engineering of EgtD enabling high-efficiency ergothioneine synthesis with a multi-enzyme cascade. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:40889650] [10.1016/j.ijbiomac.2025.147266] |
| 12. Wen Gao, Yang Wang, Fuhao Wang, Xinni Wu, Fuping Lu, Fufeng Liu. (2024) Ergothioneine exerts neuroprotective effects in Parkinson’s disease: Targeting α-synuclein aggregation and oxidative stress. FOOD RESEARCH INTERNATIONAL, [PMID:39849723] [10.1016/j.foodres.2024.115590] |
| 13. Lei Chen, Zhuomin Zhang, Zihan Guan, Jing Sun, Yanhui Sun, Mengmeng Xu, Ka-Hing Wong, Guiyang Shi, Zhongyang Ding. (2025) Enhanced ergothioneine production in Pleurotus tuber-regium through submerged fermentation optimization and selenium-driven mechanistic insights. Food Bioscience, [PMID:] [10.1016/j.fbio.2025.106146] |
| 14. Zhen Guo, Yiwen Huang, Xiaowei Wang, Yi Han, Ang Li, Yiyang Qu, Lin Chen, Meihang Du, Yiming Zhang, Yuanzhi Xu. (2025) Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis. BONE, [PMID:40287031] [10.1016/j.bone.2025.117496] |
| 15. Shuzhen Chen, Wenjing Lin, Yan Zhang, Fan Cai, Wei Lin, Jianbin Xiao, Xingtong Chen, Qin Li, Huaidong Zhang, Mingliang Zhang, Li Li. (2025) Enhancing ergothioneine production in Saccharomyces cerevisiae via protein fusion technology and gene integration optimization. Food Bioscience, [PMID:] [10.1016/j.fbio.2025.106745] |
| 16. Han Wang, Meiling Tai, Wanzhao Li, Yawen Li, Zhimeng Zhang, Dongli Zhang, Lishe Gan, Junhao Li, Xiaojuan Song, Honghong Qiu, Manmei Li, Heyun Zhang, Zhong Liu. (2025) Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers. FITOTERAPIA, [PMID:40381851] [10.1016/j.fitote.2025.106627] |
| 17. Qiuni Long, Hua Huang, Xinshuai Zhang. (2025) In vitro characterization of the ergothioneine oxidative catabolic pathway in Actinoplanes missouriensis ATCC 14538. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:40480087] [10.1016/j.bbrc.2025.152144] |
| 18. Wang Lihong, Tian Xueqin, Xue Pinghong, Deng Yunhong, Gao Rui, Hu Zhihong. (2025) Enhanced production of ergothioneine in Aspergillus oryzae. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 109 (1): (1-11). [PMID:40493205] [10.1007/s00253-025-13505-2] |
| 19. Jiahuan Ling, Rui Chen, Minghai Wang, Chun-Xiao Yan, Ruomu Xia, Lihui Zhang. (2025) Integrating Membrane Permeability Engineering and Enzyme Design for Efficient Production of Ergothioneine in E. coli. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:40478902] [10.1021/acs.jafc.5c02834] |
| 20. Liang Li, Shanshan Xu, Yanjun Jiang. (2025) Efficient production of Ergothioneine via an optimized allogenous assembly of the ERG synthesis pathway in Escherichia coli BL21. JOURNAL OF BIOTECHNOLOGY, [PMID:40523433] [10.1016/j.jbiotec.2025.06.009] |
| 21. Yifan Li, Huanhong Lu, Degang Guo, Xiaoyan Li, Fei Qi, Jian Zhang, Reinhard Fischer, Qirong Shen, Zhenzhong Yu. (2025) Light controls gene functions through alternative splicing in fungi. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 122 (26): (e2500966122). [PMID:40577119] [10.1073/pnas.2500966122] |
| 22. Yong Li, Jingyu Liu, Junlong Meng, Cuiping Feng, Jie Chen, Maomao Zeng, Hua Li. (2025) Assessment of the correlations among 1,2-dicarbonyl compounds, advanced glycation end products, and raw material chemical components of fried shiitake mushroom (Lentinula edodes) crisps. Food Chemistry-X, [PMID:41112183] [10.1016/j.fochx.2025.103128] |
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