ERK inhibitor - ≥95% , CAS No.1049738-54-6

CAS: 1049738-54-6 Cat. No.: E335372 Formule: C₁₄H₁₆N₂O₃S・HCl Poids moléculaire: 328.81

GRADE & PURITY ≥95%

Synonyms

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties. Binds preferentially to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. The compound has been shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting minimal effect on ERK1/2 phosphorylation by MEK1/2.

Specifications

Synonymes

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Spécifications et pureté

≥95%

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥95%

Noms et identifiants

• Pubchem Sid: 504768383
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768383
• Sourires canoniques: CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl
• IUPAC Name: 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione;hydrochloride
• InChIKey: PQVLWVGMXJPJLG-UHFFFAOYSA-N
• INCHI: 1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H
• Isomères SMILES: CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl
• WGK Allemagne: 3
• Poids moléculaire: 328.81
• Reaxy-Rn: 22507528
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22507528&ln=

Propriétés chimiques et physiques

• Solubilité: Soluble in DMSO (≥4 mg/mL).
• Indice de réfraction: n20D~1.65 (Predicted)

Foire aux questions

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1049738-54-6, the molecular formula is C14H16N2O3S?HCl, and the molecular weight is 328.81 g/mol. InChIKey PQVLWVGMXJPJLG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.