Estradiol valerate - Moligand™, 10mM in DMSO , Estrogen receptor alpha agonist, CAS No.979-32-8, Estrogen receptor alpha agonist

CAS: 979-32-8 Cat. No.: E409246 Molecular Weight: 356.51 Beilstein Registry Number: 2480357 EC Number: 213-559-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl pentanoate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.
In vitro

Estradiol (10 nM) rapidly activates sphingosine kinase isoenzyme SphK1 as determined by enhanced phosphorylation on Ser225 in MCF-7 cells. Estradiol (20 nM) stimulates rapid release of sphingosine 1-phosphate (S1P) and dihydro-S1P from MCF-7 cells. SphK1 and estrogen receptor α are mainly responsible for formation of S1P and dihydro-S1P. Down-regulation of ABCC1 or ABCG2 with siRNAs or pharmacological inhibitors decreases Estradiol (10 nM)-mediated release of S1P or dihydro-S1P from MCF-7 cells. Estradiol (10 nM) inhibits miR-21 expression in MCF-7 human breast cancer cells mediated by estrogen receptor α. Estradiol (10 nM) activates several miR-21 target gene reporters activity in MCF-7 cells through inhibiting miR-21 expression. Estradiol (10 nM) increases endogenous miR-21 target genes expression in protein but not RNA levels in MCF-7 cells.

In vivo

Estradiol (80 μg/kg/day, s.c.) significantly decreases the absolute numbers of total peritoneal cell and macrophages, characterized by a double F4/80- and CD11b-positive staining, in ovariectomized C57BL/6J mice. Estradiol (80 μg/kg/day, s.c.) enhances the LPS-induced expression of proinflammatory cytokines by TGC-elicited macrophages through inhibition of PI3K activity in ovariectomized C57BL/6J mice. Proinflammatory effect of Estradiol is abolished by downregulate estrogen receptor α activity in thioglycolate-elicited macrophages.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

(8R, 9S, 13S, 14S, 17S)-3-hydroxy-13-methyl-7, 8, 9, 11, 12, 13, 14, 15, 16, 17-decahydro-6H-cyclopenta[a]phenanthren-17-yl pentanoate

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Estrogen receptor alpha agonist

Product Properties

• ALogP: 6

Names and Identifiers

• Isomeric SMILES: CCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=C3C=CC(=C4)O)C
• WGK Germany: 3
• RTECS: KG5793000
• Molecular Weight: 356.51
• Beilstein: 2480357
• Reaxy-Rn: 24782553
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24782553&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 7 mg/mL (44.27 mM)
• Specific Rotation[α]: [α]D 42° (C=2,CHCl3)
• Melt Point(°C): 148 °C

References

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