Etrinabdione - 10mM in DMSO , CAS No.1818428-24-8

CAS: 1818428-24-8 Cat. No.: E656473 Formule: C₂₈H₃₅NO₃ Poids moléculaire: 433.58 PubChem CID: 118465221

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Etrinabdione (EHP-101; VCE-004.8) is an orally active, specific PPARγ and CB 2 receptor dual agonist. Etrinabdione inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. Etrinabdione, a semi-synthetic multitarget cannabinoquinoid, has potent anti-inflammatory activity. Etrinabdione attenuates adipogenesis and prevents diet-induced obesity

In Vivo

Etrinabdione (i.p.; 20?mg/kg/day; for 3 weeks) induces a significant reduction in body weight gain, total fat mass, adipocyte volume and plasma triglycerides levels in HFD mice. Etrinabdione can also significantly ameliorate glucose tolerance, reduce leptin levels (a marker of adiposity) and increase adiponectin and incretins (GLP-1 and GIP) levels . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PPARγ CB2

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Etrinabdione (EHP-101; VCE-004.8) is an orally active, specific PPARγ and CB 2 receptor dual agonist. Etrinabdione inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. Etrinabdione, a semi-synthetic multitarget cannabinoquinoid, has potent a

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Isomères SMILES: CCCCCC1=C(C(=C(C(=O)C1=O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O)NCC3=CC=CC=C3
• CAS alternatif: 1818428-24-8
• PubChem CID: 118465221
• Poids moléculaire: 433.58