Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 34 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Product Introduction
Fluconazole is used to treat adult neutropenic patients with invasive candidiasis (IC).
Application
Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.
| Pubchem Sid | 504750666 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750666 |
| Canonical Smiles | C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
| IUPAC Name | 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| InChIKey | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
| INCHI | 1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
| Isomeric SMILES | C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
| WGK Germany | 3 |
| RTECS | XZ4810000 |
| Molecular Weight | 306.27 |
| Reaxy-Rn | 4269710 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4269710&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Halobenzenes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Fluorobenzenes |
| Alternative Parents | Aryl fluorides Triazoles Tertiary alcohols Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Hydrocarbon derivatives Aromatic alcohols |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Fluorobenzene - Aryl fluoride - Aryl halide - Azole - Tertiary alcohol - 1,2,4-triazole - Heteroaromatic compound - Organoheterocyclic compound - Azacycle - Aromatic alcohol - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organopnictogen compound - Alcohol - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as fluorobenzenes. These are compounds containing one or more fluorine atoms attached to a benzene ring. |
| External Descriptors | tertiary alcohol - triazole antifungal drug - conazole antifungal drug - difluorobenzene |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Sep 19, 2025 | E129360 | |
| Certificate of Analysis | Sep 19, 2025 | E129360 | |
| Certificate of Analysis | Sep 19, 2025 | E129360 | |
| Certificate of Analysis | Sep 19, 2025 | E129360 | |
| Certificate of Analysis | Sep 19, 2025 | E129360 | |
| Certificate of Analysis | Sep 19, 2025 | E129360 | |
| Certificate of Analysis | Sep 19, 2025 | E129360 | |
| Certificate of Analysis | Feb 22, 2025 | E129360 | |
| Certificate of Analysis | Feb 22, 2025 | E129360 | |
| Certificate of Analysis | Feb 22, 2025 | E129360 | |
| Certificate of Analysis | Feb 22, 2025 | E129360 | |
| Certificate of Analysis | Feb 22, 2025 | E129360 | |
| Certificate of Analysis | Dec 04, 2024 | E129360 | |
| Certificate of Analysis | Oct 22, 2024 | E129360 | |
| Certificate of Analysis | Jul 09, 2024 | E129360 | |
| Certificate of Analysis | Jun 18, 2024 | E129360 | |
| Certificate of Analysis | Jun 18, 2024 | E129360 | |
| Certificate of Analysis | Jun 18, 2024 | E129360 | |
| Certificate of Analysis | Jun 18, 2024 | E129360 | |
| Certificate of Analysis | Jun 18, 2024 | E129360 | |
| Certificate of Analysis | Jun 18, 2024 | E129360 | |
| Certificate of Analysis | Apr 26, 2024 | E129360 | |
| Certificate of Analysis | Oct 24, 2022 | E129360 | |
| Certificate of Analysis | Apr 26, 2022 | E129360 | |
| Certificate of Analysis | Dec 21, 2021 | E129360 | |
| Certificate of Analysis | Dec 21, 2021 | E129360 | |
| Certificate of Analysis | Dec 21, 2021 | E129360 | |
| Certificate of Analysis | Dec 21, 2021 | E129360 | |
| Certificate of Analysis | Dec 21, 2021 | E129360 | |
| Certificate of Analysis | Dec 21, 2021 | E129360 | |
| Certificate of Analysis | Dec 21, 2021 | E129360 |
| Solubility | Soluble in water (<1 mg/ml at 25 °C), ethanol (61 mg/ml at 25 °C), and DMSO (61 mg/ml at 25 °C). |
|---|---|
| Melt Point(°C) | 138.0-142.0℃ |
| Molecular Weight | 306.270 g/mol |
| XLogP3 | 0.400 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 5 |
| Exact Mass | 306.104 Da |
| Monoisotopic Mass | 306.104 Da |
| Topological Polar Surface Area | 81.700 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 358.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yinzheng Ma, Jinlei Sui, Yan Wang, Wanying Sun, Guohui Yi, Jinyan Wu, Shi Qiu, Lili Wang, Aihua Zhang, Xiaowen He. (2023) RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans. MOLECULES, 28 (24): (8052). [PMID:38138542] [10.3390/molecules28248052] |
| 2. Khaing Zar Myint, Zhuoyu Zhou, Qiandai Shi, Junming Chen, Xinyu Dong, Yongmei Xia. (2023) Stevia Polyphenols, Their Antimicrobial and Anti-Inflammatory Properties, and Inhibitory Effect on Digestive Enzymes. MOLECULES, 28 (22): (7572). [PMID:38005293] [10.3390/molecules28227572] |
| 3. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu. (2023) Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen. FOOD AND CHEMICAL TOXICOLOGY, [PMID:37660943] [10.1016/j.fct.2023.114011] |
| 4. Xinying Sui, Xinyu Cheng, Zhaodi Li, Yonghong Wang, Zhenpeng Zhang, Ruyue Yan, Lei Chang, Yanchang Li, Ping Xu, Changzhu Duan. (2023) Quantitative proteomics revealed the transition of ergosterol biosynthesis and drug transporters processes during the development of fungal fluconazole resistance. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, [PMID:37307946] [10.1016/j.bbagrm.2023.194953] |
| 5. Meng Wang, Yanwen Zhou, Zhaohui Wang. (2023) Unearth the ultrapotent intrinsic fungicidal efficacy of the surface-piercing CuFeSe2-PVP nano-blade. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.142603] |
| 6. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou. (2023) Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:36919252] [10.1021/acs.jafc.2c08866] |
| 7. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] [10.3390/molecules28031479] |
| 8. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang. (2022) Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans. Infection and Drug Resistance, [PMID:33574683] [10.2147/IDR.S285690] |
| 9. Yuhao Fu, Ying Li, Yinling Ma, Xueru He, Xuejiao Xun, Yanjun Cui, Liju Fan, Zhanjun Dong. (2022) Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS. BIOMEDICAL CHROMATOGRAPHY, 37 (1): (e5525). [PMID:36241418] [10.1002/bmc.5525] |
| 10. Tao Ye, Shushu Yuan, Yu Kong, Huiqun Yang, Hongming Wei, Yuhe Zhang, Hangqi Jin, Qingxia Yu, Jiaming Liu, Songfang Chen, Jing Sun. (2022) Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota–Gut–Brain Axis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:35833673] [10.1021/acs.jafc.2c03142] |
| 11. Ma Yinzheng, Wang Yuanxiao, Zhou Xia, Yang Heng, Zhang Huixin, Chen Wenhan, Zhang Haiying, Zhang Yunxia, He Xiaowen. (2021) The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains. Scientific Reports, 11 (1): (1-10). [PMID:34608206] [10.1038/s41598-021-99188-x] |
| 12. Li Yuanjing, Yan Pengfei, Lu Xiaojie, Qiu Yanling, Liang Shang, Liu Gang, Li Shuangfei, Mou Lin, Xie Ning. (2020) Involvement of PaSNF1 in Fungal Development, Sterigmatocystin Biosynthesis, and Lignocellulosic Degradation in the Filamentous Fungus Podospora anserina. Frontiers in Microbiology, [PMID:32587577] [10.3389/fmicb.2020.01038] |
| 13. Xiaowen He, Lantong Zhang, Jinping Chen, Jinlei Sui, Guohui Yi, Jinyan Wu, Yinzheng Ma. (2019) Correlation between Chemical Composition and Antifungal Activity of Clausena lansium Essential Oil against Candida spp.. MOLECULES, 24 (7): (1394). [PMID:30970599] [10.3390/molecules24071394] |
| 14. Bingnan Wang, Siyuan Wang, Chunyang Li, Jianqing Li, Meixi Yi, Jing-Wen Lyu, Bing Gu, Ryan T.K. Kwok, Jacky W.Y. Lam, Anjun Qin, Ben Zhong Tang. (2024) An AIE fungal vacuole membrane probe toward species differentiation, vacuole formation visualization, and targeted photodynamic therapy. Materials Today Bio, [PMID:39582780] [10.1016/j.mtbio.2024.101329] |
| 15. Tingting Liu, Xiaomin Chen, Guanxuanzi Zhang, Jing Zhao, Qian Lu, Fang Wang, Hongxia Li, Bing Liu, Ping Zhu. (2024) An LCMS/MS method for the simultaneous determination of ten antimicrobials and its application in critically ill patients. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:39357099] [10.1016/j.jpba.2024.116489] |
| 16. Peng Min, Zhang Chen, Duan Yuan-Yuan, Liu Hai-Bo, Peng Xin-Yuan, Wei Qian, Chen Qi-Ying, Sang Hong, Kong Qing-Tao. (2024) Antifungal activity of the repurposed drug disulfiram against Cryptococcus neoformans. Frontiers in Pharmacology, [PMID:38273827] [10.3389/fphar.2023.1268649] |
| 17. Hao-Nan Zheng, Yu-Ru Zhi, Yang-Shuai Su, Jin-Yan Jiang, Hao-Zhou Zhang, Feng Cao, Yun Wang, Yan Chi, Ying Zhang. (2024) Dectin-1 induces TRPV1 sensitization and contributes to visceral hypersensitivity of irritable bowel syndrome in male mice. EUROPEAN JOURNAL OF PAIN, [PMID:38953581] [10.1002/ejp.2311] |
| 18. Xin-Rong Wang, Hua Zhong, Shan-Shan Ma, Ya-Hui Huang, Wei-Heng Xu, Yan Wang. (2024) Discovery of petroselinic acid with in vitro and in vivo antifungal activity by targeting fructose-1,6-bisphosphate aldolase. PHYTOMEDICINE, [PMID:39153276] [10.1016/j.phymed.2024.155948] |
| 19. Ting Fang, Juan Xiong, Xin Huang, Xinyu Fang, Xuqing Shen, Yuanying Jiang, Hui Lu. (2024) Extracellular Hsp90 of Candida albicans contributes to the virulence of the pathogen by activating the NF-κB signaling pathway and inducing macrophage pyroptosis. MICROBIOLOGICAL RESEARCH, [PMID:39522202] [10.1016/j.micres.2024.127964] |
| 20. Ming Li, Hua Sun, Jin-Ling Song, Xing Sun, Wei Li. (2025) Identification of human UDP-glucuronosyltransferases involved in I3,II8-biapigenin glucuronidation in Vitro. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:39923326] [10.1016/j.jpba.2025.116735] |
| 21. Cheng Zhen, Li Wang, Yanru Feng, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang. (2024) Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans. Advanced Science, [PMID:38995235] [10.1002/advs.202406473] |
| 22. Wanqian Li, Yanru Feng, Zhe Feng, Li Wang, Malcolm Whiteway, Hui Lu, Yuanying Jiang. (2024) Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. Antioxidants, 13 (6): (667). [PMID:38929106] [10.3390/antiox13060667] |
| 23. Qi Yuan, Yunqing Wang. (2025) SERS Detection of Hydrophobic Molecules: Thio-β-Cyclodextrin-Driven Rapid Self-Assembly of Uniform Silver Nanoparticle Monolayers and Analyte Trapping. Biosensors-Basel, 15 (1): (52). [PMID:39852103] [10.3390/bios15010052] |
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