Forsythin - analytical standard, ≥97% , CAS No.487-41-2

CAS: 487-41-2 Cat. No.: F104482 Formule: C₂₇H₃₄O₁₁ Poids moléculaire: 534.55 PubChem CID: 24721571

GRADE & PURITY Analytical standard, ≥97%

Synonyms

Phillyrin | Phillyroside | Phyllyrin | Phillygenin β-D-Glucopyranoside | 4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H | 3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl β-D-Glucopyranoside

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Specifications

Synonymes

Phillyrin | Phillyroside | Phyllyrin | Phillygenin β-D-Glucopyranoside | 4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H | 3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl β-D-Glucopyranoside

Spécifications et pureté

analytical standard, ≥97%

Conditions de stockage de stockage

Store at 2-8°C,Protected from light,Argon charged

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Étalon d'analyse

Pureté

≥97%

Noms et identifiants

• Pubchem Sid: 528775809
• Isomères SMILES: COC1=C(C=C(C=C1)[C@H]2[C@H]3CO[C@@H]([C@H]3CO2)C4=C(C=C(C=C4)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)OC)OC
• PubChem CID: 24721571
• Poids moléculaire: 534.55

Propriétés chimiques et physiques

• Sensibilité: Moisture sensitive
• Poids moléculaire: 534.600 g/mol
• XLogP3: 0.800
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 8
• Exact Mass: 534.21 Da
• Monoisotopic Mass: 534.21 Da
• Topological Polar Surface Area: 146.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 757.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Références

1. Ying Ju, Chunling Yin, Yan Zhang, Xiangru Meng, Liuchuang Zhao, Leqian Hu.  (2022)  Rapid detection and quality evaluation of Shuang-Huang-Lian injection by ATR-IR and NIR spectroscopy combined with chemometrics.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36283204] [10.1016/j.saa.2022.122008]

2. Xin Guo, Pingping Cao, Xiongfeng Lian, Meng Hu, Jingyi Zhao, Wenjing Shen, Haili Wang, Hailong Yu, Yingzhu Chen.  (2021)  The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:34425100] [10.1016/j.ejphar.2021.174439]

3. Duan Qiong, Li Ruochen, Wang Mingxiao, Cui Zhenting, Zhu Xia, Chen Fanghong, Han Feng, Ma Jianxin.  (2024)  Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,      [PMID:39356318] [10.1007/s00210-024-03481-1]

4. Chenggang Huang, Jiajia Teng, Wei Liu, Junzhe Wang, An Liu.  (2024)  Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice.  CYTOKINE,      [PMID:38417214] [10.1016/j.cyto.2024.156556]

5. Kaiping Xiang, Bing Wang, Lanying Wang, Yunfei Zhang, Hanzeng Li, Yanping Luo.  (2024)  Oxidative Stress, Oxidative Damage, and Cell Apoptosis: Toxicity Induced by Arecoline in Caenorhabditis elegans and Screening of Mitigating Agents.  Toxins,  16  (8): (352).  [PMID:39195762] [10.3390/toxins16080352]

6. Zhirui Du, Xueqiao Yan, Lin Cheng, Haiyu Shen, Guoguo Zhi, Baojie Li, Qian Yu.  (2025)  Luteolin attenuates experimental dry eye disease via dual modulation of macrophage JAK-STAT signaling and corneal epithelial MAPK pathways.  PHYTOMEDICINE,      [PMID:41005053] [10.1016/j.phymed.2025.157300]

7. Feng Li, Xinrong Fan, Bohao Wang, Jingyang Tong, Menglai Ling, Haibin Tong, Yumei Huang.  (2025)  Phillyrin counters β2 integrin-mediated neutrophil adhesion and chemotaxis to alleviate endotoxin-induced acute lung injury in neonatal rats.  BIOCHEMICAL PHARMACOLOGY,      [PMID:40210127] [10.1016/j.bcp.2025.116934]