Gastrodin - Moligand™,10mM in DMSO , CAS No.62499-27-8

CAS: 62499-27-8 Cat. No.: G408719 Formule: C₁₃H₁₈O₇ Poids moléculaire: 286.28 Numéro CE: 683-202-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Gastrodine | β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
In vitro

Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. Gastrodin (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes.

In vivo

Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS can facilitate memory consolidation and retrieval, but not acquisition. LD50: Mice >1000mg/kg (i.v.)
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonymes

Gastrodine | β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl

Spécifications et pureté

Moligand™,10mM in DMSO

Mécanismes biochimiques et physiologiques

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Noms et identifiants

Isomères SMILES

C1=CC(=CC=C1CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O

Poids moléculaire

286.28

Reaxy-Rn

25441801

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25441801&ln=

Propriétés chimiques et physiques

• Rotation spécifique [α]: -66.0 to -70.0 deg(C=1,H2O)
• Point de fusion (°C): 154-155°C