GL0388 - ≥98% , CAS No.G659418

CAS: G659418 Cat. No.: G659418 Molecular Weight: 332.37

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC 50 s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis . GL0388 sup

Appearance:Solid

IC50& Target:Bax

In Vitro:GL0388 (0.1-10 μM; 72 h) inhibits the cell proliferation of MDA-MB-231 and MCF-7 breast cancer cell lines, with IC 50 s of 0.96 μM and 0.52 μM, respectively. GL0388 (0.01-100 μM) inhibits the cell proliferation in 60 human tumor cell lines, with GI5

In Vivo:GL0388 (10-20mg/kg for i.p.; 15mg/kg for i.t.; once daily for 10 days) dose-dependently suppresses the growth of MDA-MB-231 tumors in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model

Biological Activity:GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC 50 s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis . GL0388 sup

Specifications

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 332.37