Gliclazide - 10mM in DMSO , Sulfonylurea receptor 1, Kir6.2 blocker, CAS No.21187-98-4, Sulfonylurea receptor 1, Kir6.2 blocker

CAS: 21187-98-4 Cat. No.: G408517 Formule: C₁₅H₂₁N₃O₃S Poids moléculaire: 323.41 Numéro CE: 244-260-5

GRADE & PURITY 10mM in DMSO

Synonyms

N-​[[(hexahydrocyclopen​ta[c]​pyrrol-​2(1H)​-​yl)​amino]​carbonyl]​-​4-​methyl-benzenesulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Gliclazide Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonymes

N-​[[(hexahydrocyclopen​ta[c]​pyrrol-​2(1H)​-​yl)​amino]​carbonyl]​-​4-​methyl-benzenesulfonamide

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

BLOCKER

Mécanisme d'action

Sulfonylurea receptor 1, Kir6.2 blocker

Propriétés du produit

• ALogP: 1.5

Noms et identifiants

• Isomères SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
• WGK Allemagne: 2
• RTECS: YT4500000
• Poids moléculaire: 323.41
• Reaxy-Rn: 1657836
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1657836&ln=

Propriétés chimiques et physiques

• Point de fusion (°C): 165.0-169.0℃

Références

1. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li.  (2023)  An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods.  Foods,  12  (3): (539).  [PMID:36766067] [10.3390/foods12030539]

2. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei.  (2021)  Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea.  FOOD CHEMISTRY,      [PMID:34536782] [10.1016/j.foodchem.2021.131055]

3. Jiankun Cao, Qing Jiang, Ruixian Li, Qian Xu, Hongli Li.  (2019)  Nanofibers mat as sampling module of direct analysis in real time mass spectrometry for sensitive and high-throughput screening of illegally adulterated sulfonylureas in antidiabetic health-care teas.  TALANTA,      [PMID:31357362] [10.1016/j.talanta.2019.06.066]

4. Lele Wang, Tijie Duan, Yawen Gao, Heqing Liu, Rui Sun, Tong Wu, Jihui Tang.  (2025)  Development and in vitro-in vivo evaluation of a novel sustained-release tablet based on constant-release surface.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.106603]