GLXC-26326 - Moligand™, ≥98% , Inhibitor of ribosomal protein S6 kinase B1, CAS No.1226801-23-5, Inhibitor of ribosomal protein S6 kinase B1

CAS: 1226801-23-5 Cat. No.: G610596 Formule: C₂₅H₂₇F₄N₇O Poids moléculaire: 517.52 PubChem CID: 46186926

GRADE & PURITY Moligand™, ≥98%

Synonyms

example 45 [WO2010056563A1];GLXC26326;LY-2780301;LY2780301

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Specifications

Synonymes

example 45 [WO2010056563A1];GLXC26326;LY-2780301;LY2780301

Spécifications et pureté

Moligand™, ≥98%

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Inhibitor of ribosomal protein S6 kinase B1

Pureté

≥98%

Noms et identifiants

• Pubchem Sid: 528764613
• Sourires canoniques: CN(C)CCN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3CC(=O)N4)C5=CC(=C(C=C5)F)C(F)(F)F
• InChIKey: YDFKZIGAUIKZGP-UHFFFAOYSA-N
• INCHI: 1S/C25H27F4N7O/c1-34(2)9-10-36-13-20(16-3-4-19(26)18(11-16)25(27,28)29)32-23(36)15-5-7-35(8-6-15)24-17-12-21(37)33-22(17)30-14-31-24/h3-4,11,13-15H,5-10,12H2,1-2H3,(H,30,31,33,37)
• Isomères SMILES: CN(C)CCN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3CC(=O)N4)C5=CC(=C(C=C5)F)C(F)(F)F
• PubChem CID: 46186926
• Poids moléculaire: 517.52

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Imidazoles
        • Level5 Substituted imidazoles
          • Level6 Phenylimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Substituted imidazoles
• Direct Parent: Phenylimidazoles
• Alternative Parents: Trifluoromethylbenzenes Pyrrolopyrimidines 1,2,4-trisubstituted imidazoles Dialkylarylamines Aminopyrimidines and derivatives Fluorobenzenes Aryl fluorides Piperidines Imidolactams N-substituted imidazoles Heteroaromatic compounds Pyrroles Amino acids and derivatives Trialkylamines Lactams Secondary carboxylic acid amides Azacyclic compounds Hydrocarbon derivatives Alkyl fluorides Carbonyl compounds Organic oxides Organofluorides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 5-phenylimidazole - 4-phenylimidazole - Trifluoromethylbenzene - Pyrrolopyrimidine - 1,2,4-trisubstituted-imidazole - Dialkylarylamine - Trisubstituted imidazole - Fluorobenzene - Aminopyrimidine - Halobenzene - Aryl fluoride - Piperidine - Benzenoid - N-substituted imidazole - Monocyclic benzene moiety - Aryl halide - Imidolactam - Pyrimidine - Pyrrole - Heteroaromatic compound - Amino acid or derivatives - Lactam - Secondary carboxylic acid amide - Tertiary amine - Carboxamide group - Tertiary aliphatic amine - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Organohalogen compound - Organofluoride - Carbonyl group - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

RPS6KB1 Tchem Ribosomal protein S6 kinase beta-1 (0 Activities)

Discover Target: RPS6KB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)