Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.
Application：
Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.
| Pubchem Sid | 504753816 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753816 |
| Canonical Smiles | CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N |
| IUPAC Name | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid;azane |
| InChIKey | ILRKKHJEINIICQ-OOFFSTKBSA-N |
| INCHI | 1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1 |
| Isomeric SMILES | C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O.N |
| Molecular Weight | 839.96 |
| Reaxy-Rn | 30023600 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30023600&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Prenol lipids |
| Subclass | Terpene glycosides |
| Intermediate Tree Nodes | Triterpene glycosides |
| Direct Parent | Triterpene saponins |
| Alternative Parents | Triterpenoids O-glucuronides Disaccharides O-glycosyl compounds Tricarboxylic acids and derivatives Beta hydroxy acids and derivatives Cyclohexenones Pyrans Oxanes Secondary alcohols Acetals Polyols Carboxylic acids Oxacyclic compounds Organic oxides Hydrocarbon derivatives Organic nitrogen compounds |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Triterpene saponin - Triterpenoid - 1-o-glucuronide - O-glucuronide - Glucuronic acid or derivatives - Disaccharide - Glycosyl compound - O-glycosyl compound - Tricarboxylic acid or derivatives - Cyclohexenone - Beta-hydroxy acid - Pyran - Hydroxy acid - Oxane - Secondary alcohol - Ketone - Organoheterocyclic compound - Polyol - Acetal - Carboxylic acid - Carboxylic acid derivative - Oxacycle - Organic oxide - Organic oxygen compound - Alcohol - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organooxygen compound - Aliphatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as triterpene saponins. These are glycosylated derivatives of triterpene sapogenins. The sapogenin moiety backbone is usually based on the oleanane, ursane, taraxastane, bauerane, lanostane, lupeol, lupane, dammarane, cycloartane, friedelane, hopane, 9b,19-cyclo-lanostane, cycloartane, or cycloartanol skeleton. |
| External Descriptors | organic molecular entity |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2310328 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310329 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310330 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310333 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310334 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310335 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310336 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310337 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310338 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310339 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310341 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310343 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310344 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| G2310346 | Certificate of Analysis | Apr 07, 2026 | G302828 |
| Solubility | Ethanol:<1 mg/mL;H2O:5 mg/mL (5.95 mM);DMSO:155 mg/mL (184.5 mM) |
|---|---|
| Molecular Weight | 840.000 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 9 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 7 |
| Exact Mass | 839.43 Da |
| Monoisotopic Mass | 839.43 Da |
| Topological Polar Surface Area | 268.000 Ų |
| Heavy Atom Count | 59 |
| Formal Charge | 0 |
| Complexity | 1730.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 19 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
| 1. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu. (2023) Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37704122] [10.1016/j.jep.2023.117136] |
| 2. Jiajia Jin, Jun chen, Xin Shou, Keqing Shi, Xingjie Zan, Yan Zu, Xiaoying Huang. (2023) MAG-encapsulated PLGA microspheres for Lipopolysaccharide-induced acute lung injury. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2023.104632] |
| 3. Guanhua Li, Sheng Li. (2022) Resources recycle of traditional Chinese medicine (TCM) wastewater 2: The UF-FO-MD hybrid system and wetting prevention. DESALINATION, [PMID:] [10.1016/j.desal.2022.115968] |
| 4. Wenwei Zhong, Yingnan Zhao, Shunquan Chen, Jialun Zhong, LiWei Guo, Dongyang Zheng, Chun Xie, Chao Ji, Yi Guo, Guangxi Dong, Fengyuan Zhang, Alicia An, Shaoping Li, Sheng Li. (2021) Resources recycle of traditional Chinese medicine (TCM) wastewater 1: Effectiveness of the UF-MD hybrid system and MD process optimization. DESALINATION, [PMID:] [10.1016/j.desal.2021.114953] |
| 5. Yan Zhang, Zhaojun Wang, Weimin Zhou, Guoquan Min, Meidong Lang. (2013) Cationic poly(ɛ-caprolactone) surface functionalized mesoporous silica nanoparticles and their application in drug delivery. APPLIED SURFACE SCIENCE, [PMID:] [10.1016/j.apsusc.2013.03.168] |
| 6. Yan Zhang, Jianjing Liu, Yutong Fu, Ke Tan, Zhaoyang Ye, Meidong Lang. (2013) Self-assembly of polyion complex nanocarriers from ammonium glycyrrhizinate and monomethoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone). Journal of Materials Chemistry B, 1 (11): (1614-1621). [PMID:32260724] [10.1039/C3TB00012E] |
