Factor XIa, CAS No.37203-61-5

CAS: 37203-61-5 Cat. No.: H1443844

QUALITÉ & PURETÉ Bioactive, ActiBioPure™, Native, High Performance, EnzymoPure™, ≥95%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Accession #

P03951

Bioactivity

See COA

Vue d’ensemble

  Prepared from Human Factor XI using Human Factor Xlla. This Xlla was removed using a corn trypsin inhibitor column. Complete activation is observed by SDS-PAGE. Factor XI, through the contact factor pathway cascade, is activated to Factor XIa via Factor Xlla and High Molecular Weight Kininogen. During activation by Factor Xlla and HK, FXI undergoes proteolytic cleavage in which the Mr=80,000 chain reportedly is cleaved to a heavy and light chain with Mr of about 48,000 and 33,000. This Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of Vitamin K-dependent blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces.

  Extinction Coefficient (1%) = 13.1

  The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD. 

Spécifications

Product Name

Factor XIa, CAS No.37203-61-5

Synonymes

Human Factor XIa Native Protein | Coagulation Factor XIa, Human Plasma | coagulation factor XIa | plasma thromboplastin antecedent | Coagulation factor XI | F11 | FXI | PTA

Grade

ActiBioPure™, Bioactive, High Performance, Native, EnzymoPure™

Spécifications et pureté

Bioactive,ActiBioPure™,Native,High Performance,EnzymoPure™,≥95%(SDS-PAGE),from Human plasma; Protein concentration: See COA

Mécanismes biochimiques et physiologiques

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Catalytic activity: Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. Activity regulation: Inhibited by SERPINA5.

Bioactivité

See COA

Accession #

P03951

Poids moléculaire prévu

160 kDa

CAS

37203-61-5

Numéro de commission de l'enzyme

EC 3.4.21.27

Type de molécule

Enzyme

Product Line

Produits biologiques

Stockage et expédition

Concentration

from Human plasma; Protein concentration: See COA

Conditions de stockage de stockage

Store at -80°C,Avoid repeated freezing and thawing

Expédié en

Dry ice packs + Cold packs

Stabilité et stockage

Store at -80℃ long term. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Foire aux questions

What is ActiBioPure??

ActiBioPure? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, ActiBioPure? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

What does Bioactive mean?

Bioactive indicates that the product has been processed and tested for biological and biochemical applications. Specifications may include endotoxin limits, microbial controls, sterility, low DNase/RNase/protease activity, and verified biological activity where relevant.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 37203-61-5.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

What is the purity of this product, and how is it determined?

This product is supplied at ≥95% purity, determined by SDS-PAGE. Lot-specific values are stated on the Certificate of Analysis.