Icariin - ≥96% , CAS No.489-32-7

CAS: 489-32-7 Cat. No.: I141014 Molecular Weight: 676.66 EC Number: 610-440-0 PubChem CID: 5318997

GRADE & PURITY ≥96%

Synonyms

3-((6-Deoxymannopyranosyl)oxy)-7-(glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one | 5-HYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUT-2-EN-1-YL)-7-{[3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]OXY}-3-[(3,4,5-TRIHYD

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

3-((6-Deoxymannopyranosyl)oxy)-7-(glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one | 5-HYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUT-2-EN-1-YL)-7-{[3, 4, 5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]OXY}-3-[(3, 4, 5-TRIHYD

Specifications & Purity

≥96%

Biochemical and Physiological Mechanisms

Selective cGMP specific PDE5 inhibitor (IC 50 = 0.4 and 74 μM for PDE5 and PDE4 respectively). Shows anti-inflammatory and antitumor effects in vivo . Orally active.

Storage

Room temperature

Shipped In

Normal

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥96%

Names and Identifiers

• Pubchem Sid: 488195337
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195337
• Canonical Smiles: COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2
• IUPAC Name: 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
• InChIKey: TZJALUIVHRYQQB-XLRXWWTNSA-N
• INCHI: 1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
• Isomeric SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O
• WGK Germany: 3
• PubChem CID: 5318997
• Molecular Weight: 676.66

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Flavonoids
      • Subclass Flavonoid glycosides
        • Level5 Flavonoid O-glycosides
          • Level6 Flavonoid-7-O-glycosides

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Flavonoids
• Subclass: Flavonoid glycosides
• Intermediate Tree Nodes: Flavonoid O-glycosides
• Direct Parent: Flavonoid-7-O-glycosides
• Alternative Parents: 8-prenylated flavones Flavonoid-3-O-glycosides 4'-O-methylated flavonoids 5-hydroxyflavonoids Phenolic glycosides Chromones O-glycosyl compounds Anisoles Methoxybenzenes Phenoxy compounds 1-hydroxy-2-unsubstituted benzenoids Alkyl aryl ethers Pyranones and derivatives Monosaccharides Oxanes Vinylogous acids Heteroaromatic compounds Secondary alcohols Polyols Acetals Oxacyclic compounds Hydrocarbon derivatives Primary alcohols Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 8-prenylated flavone - Flavonoid-3-o-glycoside - Flavonoid-7-o-glycoside - 4p-methoxyflavonoid-skeleton - Hydroxyflavonoid - Flavone - 5-hydroxyflavonoid - Phenolic glycoside - Glycosyl compound - O-glycosyl compound - Chromone - Benzopyran - 1-benzopyran - Methoxybenzene - Phenol ether - Phenoxy compound - Anisole - Alkyl aryl ether - Pyranone - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Pyran - Monosaccharide - Oxane - Benzenoid - Heteroaromatic compound - Vinylogous acid - Secondary alcohol - Acetal - Oxacycle - Organoheterocyclic compound - Polyol - Ether - Organic oxide - Organic oxygen compound - Primary alcohol - Alcohol - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as flavonoid-7-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position.
• External Descriptors: Flavones and Flavonols

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

Discover Target: PDE5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLB Tchem DNA polymerase beta (23632 Activities)

Discover Target: POLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)

Discover Target: KDM1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

PDE6C Phosphodiesterase 6C (1 Activities)

Discover Target: PDE6C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Heat Sensitive
• Specific Rotation[α]: -84° (C=1,Pyridine)
• Melt Point(°C): 235 - 239°C
• Molecular Weight: 676.700 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 9
• Exact Mass: 676.237 Da
• Monoisotopic Mass: 676.237 Da
• Topological Polar Surface Area: 234.000 Ų
• Heavy Atom Count: 48
• Formal Charge: 0
• Complexity: 1170.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 10
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Bin Wang, Yanbin Zhao, Yangyang Li, Chengliang Tang, Peng He, Xiaowei Liu, Junyan Yao, Chenglin Chu, Bin Xu.  (2023)  NIR-responsive injectable magnesium phosphate bone cement loaded with icariin promotes osteogenesis.  Journal of the Mechanical Behavior of Biomedical Materials,      [PMID:38048713] [10.1016/j.jmbbm.2023.106256]

2. Jia Ji, Zhao Xing-an, Tao Si-ming, Wang Jun-wen, Zhang Rong-liang, Dai Hua-lei, Zhang Xin-jin, Han Ming-hua, Yang Bei, Li Yu, Li Jin-tao.  (2023)  Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction.  EUROPEAN JOURNAL OF MEDICAL RESEARCH,  28  (1): (1-12).  [PMID:38115154] [10.1186/s40001-023-01588-4]

3. Jinping Wang, Lingrong Wen, Yueming Jiang, Hong Zhu, Weizheng Sun, Guangyi Dai, Bao Yang.  (2023)  Structure, bioavailability and physicochemical properties of icariin-soymilk nanoparticle.  Food Science and Human Wellness,      [PMID:] [10.26599/FSHW.2022.9250083]

4. Wanwu Dai, Pan Jin, Xingyan Li, Jinmin Zhao, Ying Lan, Hongmian Li, Li Zheng.  (2023)  A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:37210895] [10.1016/j.biopha.2023.114881]

5. Lin Yu, Chen Wen-wen, Ding Bo, Guo Man, Liang Meng, Pang Hao, Wei Yu-tuo, Huang Ri-bo, Du Li-qin.  (2023)  Highly efficient bioconversion of icariin to icaritin by whole-cell catalysis.  Microbial Cell Factories,  22  (1): (1-11).  [PMID:37016390] [10.1186/s12934-023-02068-4]

6. Simin Deng, Yuan Xu, Binbin Gao, Tingting Yu, Lun Kuang, Bo’ang Han, Shaolun Feng, Haodong Chi, Qing Cao, Shen Yue, Chen Liu.  (2023)  Anemarrhenasaponin I suppresses ovarian cancer progression via inhibition of SHH signaling pathway.  Oncologie,  25  (3): (233-243).  [PMID:] [10.1515/oncologie-2022-1001]

7. Yang Du, Fengjiao Zhao, Junpeng Xing, Zhiqiang Liu, Meng Cui.  (2023)  Stabilization of Labile Lysozyme–Ligand Interactions in Native Electrospray Ionization Mass Spectrometry.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,      [PMID:36735536] [10.1021/jasms.2c00238]

8. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng.  (2023)  Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:36724705] [10.1016/j.plaphy.2023.01.050]

9. Yu Li-Ming, Dong Xue, Huang Tao, Zhao Ji-Kai, Zhou Zi-Jun, Huang Yu-Ting, Xu Yin-Li, Zhao Qiu-Sheng, Wang Zhi-Shang, Jiang Hui, Yin Zong-Tao, Wang Hui-Shan.  (2023)  Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1.  APOPTOSIS,  28  (3): (607-626).  [PMID:36708428] [10.1007/s10495-023-01814-8]

10. LI Gang, GE Xiaohong.  (2023)  Interaction mechanism of icariin and whey protein based on spectrofluorimetry and molecular docking.  Food Science and Technology,      [PMID:] [10.1590/fst.102822]

11. Jinping Wang, Hong Zhu, Yueming Jiang, Jianbo Xiao, Bao Yang, Lingrong Wen.  (2022)  Fabrication of icariin-soymilk nanoparticles with ultrasound-assisted treatment.  ULTRASONICS SONOCHEMISTRY,      [PMID:36436486] [10.1016/j.ultsonch.2022.106230]

12. Li-Ming Yu, Xue Dong, Yin-Li Xu, Zi-Jun Zhou, Yu-Ting Huang, Ji-Kai Zhao, Deng-Yue Xu, Xiao-Dong Xue, Qiu-Sheng Zhao, Tao Liu, Zong-Tao Yin, Hui Jiang, Hui-Shan Wang.  (2022)  Icariin attenuates excessive alcohol consumption-induced susceptibility to atrial fibrillation through SIRT3 signaling.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,      [PMID:35798229] [10.1016/j.bbadis.2022.166483]

13. Cui Zhanding, Wang Qian, Li Dengliang, Zhao Shihui, Zhang Qian, Tan Yuxin, Gong Qianwen, Liu Ting, Shao Jiang, Zhang Shuang, Huang Hailong, Wang Junzheng, Pei Zhihua, Dong Hao, Wang Kai, Hu Guixue, Li Zhiyong.  (2021)  Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro.  ARCHIVES OF VIROLOGY,  166  (9): (2443-2450).  [PMID:34173062] [10.1007/s00705-021-05107-w]

14. Li Chunyang, Yang Shuangqing, Ma Huaqing, Ruan Mengjia, Fang Luyan, Cheng Jing.  (2021)  Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-κB and Wnt/β-catenin pathways.  Cancer Cell International,  21  (1): (1-14).  [PMID:33849528] [10.1186/s12935-021-01910-2]

15. Xiaoang Li, Imran Khan, Wenrui Xia, Guoxin Huang, Liang Liu, Betty Yuen Kwan Law, Lin Yin, Weilin Liao, Waikit Leong, Ruixuan Han, Vincent Kam Wai Wong, Chenglai Xia, Xiaoling Guo, W.L. Wendy Hsiao.  (2021)  Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice.  PHARMACOLOGICAL RESEARCH,      [PMID:33798737] [10.1016/j.phrs.2021.105587]

16. Yanzheng Xie, Lei Xie, Ailan Chen, Shengnan Wu, Yuxiao Mo, Xiaoqiang Guo, Changchun Zeng, Xinan Huang, Jinyang He.  (2020)  Anti-HIV/SIV activity of icariin and its metabolite anhydroicaritin mainly involve reverse transcriptase.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:32726656] [10.1016/j.ejphar.2020.173327]

17. Wenbin Hua, Shuai Li, Rongjin Luo, Xinghuo Wu, Yukun Zhang, Zhiwei Liao, Yu Song, Kun Wang, Kangcheng Zhao, Shuhua Yang, Cao Yang.  (2019)  Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,      [PMID:31666206] [10.1016/j.bbadis.2019.165575]

18. Yuanlong Xie, Wenchao Sun, Feifei Yan, Huowen Liu, Zhouming Deng, Lin Cai.  (2019)  Icariin-loaded porous scaffolds for bone regeneration through the regulation of the coupling process of osteogenesis and osteoclastic activity.  International Journal of Nanomedicine,      [PMID:31534334] [10.2147/IJN.S203859]

19. Zhou Mengmeng, Jiang Zehua, Zhang Maosen, Feng Sa, Ma Boyuan, Kan Shunli, Fu Xuanhao, Zhu Rusen.  (2025)  Exploring the molecular mechanism of icariin improving spinal cord injury through network pharmacology combined with experimental verification.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,      [PMID:40014127] [10.1007/s00210-025-03904-7]

20. Nannan Ding, Shanyue Sun, Shuting Zhou, Zhimei Lv, Rong Wang.  (2024)  Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2-mediated attenuation of mitochondrial damage.  CELL BIOCHEMISTRY AND FUNCTION,  42  (3): (e4005).  [PMID:38583082] [10.1002/cbf.4005]

21. Huizhen Tian, Qigang Pan, Jianfeng Wu, Juanjuan Liao, Yuwei Wan, Ke Pei, Qiong Liu, Lingbing Zeng, Yanli Cao, Qiaofa shi, Nanzhen Kuang, LiJuan Sun, Xiaomin Yu, Xiaotian Huang.  (2024)  Icariin ameliorates Coxsackievirus B3-induced viral myocarditis by modulating the S100 calcium binding protein A6/β-catenin/c-Myc signaling pathway.  PHYTOMEDICINE,      [PMID:39522251] [10.1016/j.phymed.2024.156214]

22. Wang Haoyue, Sun Kexiang, Tan Wei Shan, Gao Jiamin, Yuan Luyun, Wen Junkai, Deng Wanli.  (2024)  Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors.  PHYTOMEDICINE,      [PMID:39642461] [10.1016/j.phymed.2024.156224]

23. Feng Sa, Liu Linyan, Cheng Yuelin, Zhou Mengmeng, Zhu Haoqiang, Zhao Xinyan, Chen Ziyu, Kan Shunli, Fu Xuanhao, Hu Wei, Zhu Rusen.  (2024)  Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes.  Frontiers in Pharmacology,      [PMID:39439899] [10.3389/fphar.2024.1434652]

24. Song Wang, Xinnan Chang, Jing Li, Zuoqiao Shi, Guowen Li.  (2025)  Identification of chemical components and metabolites in rats after oral administration of Epimedium-Astragalus granule pair by liquid chromatography-high resolution mass spectrometry combined with diagnostic fragment ions and mass defect filtering.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:40014893] [10.1016/j.jpba.2025.116768]

25. Jiaojiao Ding, Tiexiang Gao, Songlin Liu, Zhezhe Li, Baifei Hu, Junping Zhen, Xiaowei Yao, Hongtao Liu, Haiming Hu.  (2025)  Rhamnosidase from Parabacteroides distasonis exhibit the catabolism of epimedin C in the human gut microbiota.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40157660] [10.1016/j.ijbiomac.2025.142481]

26. Jiayi Zhang, Jingzhi Wang, Junfeng Wang, Weifeng Ni, Shichao Liu, Daqing Zhao, Zhengqi Dong, Shiting Yu, Siming Wang, Weinan Wang, Meichen Liu.  (2025)  Integrated multi-omics and machine learning reveal the intrinsic relationship between color and flavor variations in processed ginseng products through major pigment dynamics and non-enzymatic pathways.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2025.118161]

27. Yimin Sun, Xuetao Yang, Yin Liu, Chenxi Zhang, Huiyu Feng, Dongdong Wu, Ling Ye, Fanyuan Yu, Feifei Li.  (2025)  Adaptive Cationic Peptide Bundles Hydrogel for the Repair of Infected Mandibular Defects.  BIOMATERIALS,      [PMID:40818323] [10.1016/j.biomaterials.2025.123613]

28. Qingdi Qu, Qian Zhang, Mengyuan Wang, Shuang Zhao, Ping Li, Chenxi Shang, Yumei Niu, Shuang Zhang, Shuang Pan.  (2025)  Study on the effect of sustained -release icariin-loaded Graphene oxide-hydrogel composite scaffold on bone defect repair.  Biomedical Physics & Engineering Express,  11  (5): (055018).  [PMID:40774284] [10.1088/2057-1976/adf8ee]

29. Hongxia Fan, Jiansong Zhao, Zhencheng Gao, Yinling Mu, Xiaoman Zhang, Wanbing Pan, Sishu Li, Haibing He, Jingxin Gou, Xing Tang, Tian Yin, Yu Zhang.  (2025)  Injectable self-healing hydrogel loaded PLGA nanoparticles for long-term osteoarthritis therapy.  Biomaterials Advances,      [PMID:41005083] [10.1016/j.bioadv.2025.214506]

30. Han Yan, Yuhao Liao, Weixiong Chen, Junnan Luo, Dongdong Li, Jilong Wang, Faxin Liu.  (2025)  Bone-targeted nanomedicine based on red blood cell membrane-coated polymeric carriers for effective osteoporosis reversal.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.107063]

31. Wei Hu, Chen Li, Chenguang Wang, Wei Liu, Chuntong Li, Lihua Mu, Kun Wang, Mengli Chen.  (2025)  Exploring the therapeutic mechanism of Miao nationality medicine Qijiao Shengbai capsule on leukopenia based on multi-omics, network pharmacology and experimental verification.  PHYTOMEDICINE,      [PMID:40513324] [10.1016/j.phymed.2025.156935]

32. Wei Yusen, Mao Jiangdi, Tang Wenjie, Ma Yanfei, Li Jiachen, Su Songtao, Ni Zhixiang, Wu Jinhong, Liu Daren, Wang Haifeng.  (2025)  Targeting Catenibacterium mitsuokai with icariin modulates gut microbiota and improves hepatic lipid metabolism in intrauterine growth restriction.  ISME Journal,      [PMID:40607758] [10.1093/ismejo/wraf141]

33. Yongbin Wang, Han Zhang, Zhili Xu, Weihang Zhu, Sheng Chang, Jiahao Wei, Shuqing Chen, Yong Liu, Weiqing Kong, Jianwei Guo.  (2025)  Icariin-loaded GelMa Hydrogel Encapsulated Potassium Sodium Niobate Biomimetic Piezoelectric Scaffold Regulates Macrophage Polarization to Accelerate Bone Defect Repair.  Materials Today Bio,      [PMID:41281663] [10.1016/j.mtbio.2025.102476]

34. Yongmei Chen, Qingwen Wei, Jing Wang, Chuanyao Huang, Zhenghao Wang, Yuchun Liu.  (2025)  Studies on the Flavonoid Composition of Pleioblastus amarus Leaves and Shoots Based on Targeted Metabolomics.  Metabolites,  15  (11): (709).  [PMID:41295295] [10.3390/metabo15110709]

35. Jingfeng Sun, Jinying Li, Peining She, Yang Xiao, Tao Zhang, Guorui Li, Jiaming Ye, Zhanlun Ou, Jianghao Bi, Shaochuan Li.  (2025)  Polydopamine coating for anchoring icariin-regulated CF/PEEK with enhanced cytocompatibility and osteogenic activity.  Journal of Materials Chemistry B,      [PMID:41246930] [10.1039/D5TB02014J]

36. Bin-Chun Li, Weijuan Dong, Bingbing Wu, Yanlong Liu, Na Han, Guo-Bin Ding.  (2025)  Characterization of a Thermophilic and Acidophilic GH78 α-L-Rhamnosidase from Thermotoga sp. 2812B Capable of Efficiently Hydrolyzing a Variety of Natural Flavonoid Diglycosides.  Biomolecules,  16  (1): (68).  [PMID:41594608] [10.3390/biom16010068]

37. Dahe Qiao, Chun Yang, Xiaozeng Mi, Sihui Liang, Yan Guo, Juan Chen, Zhengwu Chen.  (2026)  Comprehensive evaluation of tea processing quality characteristics in ‘Qiancha 1′ tea plant cultivar: chemical profiling across tea types from multi-grade raw materials.  Applied Food Research,  6  (1): (101723).  [PMID:] [10.1016/j.afres.2026.101723]

38. Changxu Wang, Shenghao Shi, Fei Wang, Chong Yuan, Di Liu, Yifei Liu.  (2026)  A biointerface-engineered gold nanocluster platform for icariin delivery: Dual-pathway modulation of osteoblast and osteoclast dynamics in osteoporosis therapy.  Biomaterials Advances,      [PMID:41691763] [10.1016/j.bioadv.2026.214773]