Imiloxan(RS-21361) - Moligand™,≥98% , Antagonist of α 2B-adrenoceptor, CAS No.81167-16-0, Antagonist of α 2B-adrenoceptor

CAS: 81167-16-0 Cat. No.: I611041 Formule: C₁₄H₁₆N₂O₂ Poids moléculaire: 244.29

GRADE & PURITY Moligand™, ≥98%

Synonyms

NCGC00015570-04 | GNF-Pf-2156 | Tox21_110175_1 | Imiloxano [Spanish] | PDSP2_001483 | 1H-Imidazole, 2-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl- | Propyl 3,5-diiodo-4-oxo-1(4H)-pyridineacetate | (+-)-2-(1,4-Benzodioxan-2-ylmethyl)-1-ethylimidazol

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonymes

NCGC00015570-04 | GNF-Pf-2156 | Tox21_110175_1 | Imiloxano [Spanish] | PDSP2_001483 | 1H-Imidazole, 2-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl- | Propyl 3,5-diiodo-4-oxo-1(4H)-pyridineacetate | (+-)-2-(1,4-Benzodioxan-2-ylmethyl)-1-ethylimidazol

Spécifications et pureté

Moligand™,≥98%

Mécanismes biochimiques et physiologiques

Imiloxan (RS 21361) is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan produces a dose-related reversal of Guanoxabenz-induced maximal mydriasis in male rats. Imiloxan has the potential for acute kidney injury research.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ANTAGONIST

Mécanisme d'action

Antagonist of α 2B-adrenoceptor

Pureté

≥98%

Noms et identifiants

• Sourires canoniques: CCn1ccnc1CC1COc2c(O1)cccc2
• IUPAC Name: 2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-ethylimidazole
• InChIKey: UXABARREKCJULM-UHFFFAOYSA-N
• INCHI: 1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3
• Isomères SMILES: CCN1C=CN=C1CC2COC3=CC=CC=C3O2
• Poids moléculaire: 244.29

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzodioxanes
      • Subclass Benzo-1,4-dioxanes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzodioxanes
• Subclass: Benzo-1,4-dioxanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzo-1,4-dioxanes
• Alternative Parents: Alkyl aryl ethers Para dioxins N-substituted imidazoles Benzenoids Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzo-1,4-dioxane - Alkyl aryl ether - N-substituted imidazole - Para-dioxin - Benzenoid - Azole - Imidazole - Heteroaromatic compound - Ether - Azacycle - Oxacycle - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as benzo-1,4-dioxanes. These are heterocyclic compounds containing a benzene ring fused to a 1,4-dioxane ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

ADRA2B Tclin Alpha-2B adrenergic receptor (1 Activities)

Discover Target: ADRA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCB11 Tchem Bile salt export pump (2311 Activities)

Discover Target: ABCB11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adra1b Adrenergic receptor alpha-1 (5652 Activities)

Discover Target: Adra1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adra2c Adrenergic receptor alpha-2 (3313 Activities)

Discover Target: Adra2c

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Poids moléculaire: 244.290 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 244.121 Da
• Monoisotopic Mass: 244.121 Da
• Topological Polar Surface Area: 36.300 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 275.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Références

1. Yue Wang, Guojun Pan, Tingjie Huang, Tao Zhang, Jin Lin, Lubin Song, Guangshuo Zhou, Xiaoping Ma, Yanqing Ge, Yongyu Xu, Chunhao Yuan, Nan Zou.  (2023)  Exogenous tannic acid relieves imidacloprid-induced oxidative stress in tea tree by activating antioxidant responses and the flavonoid biosynthetic pathway.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:37820476] [10.1016/j.ecoenv.2023.115557]

2. Yong Yang, Xinxin Ma, Zifen Li, Yanru Wang, Chao Ju, Lidong Cao, Yongquan Zheng, Qingming Zhang.  (2023)  ZIF-8 and humic acid modified magnetic corn stalk biochar: An efficient, magnetically stable, and eco-friendly adsorbent for imidacloprid and thiamethoxam removal.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.142788]

3. Chao Zhang, Huike Zhang, Xin Wan, Yue Xie, Michael J. Bentel, Zhanjiang Yu, Zhenguo Chen, Jiaan He, Junlang Li, Xuezhu Xiang, Xinzhi Wang, Zhaoli Wang, Guang-Guo Ying, Dionysios D. Dionysiou, Mingzhi Huang.  (2023)  Nitrogen-Doped Graphdiyne Nanotubes for Metal-Free Activation of Peroxymonosulfate and Enhanced Degradation of Recalcitrant Heterocyclic Contaminants.  ACS ES&T Engineering,      [PMID:] [10.1021/acsestengg.3c00009]

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 81167-16-0, the molecular formula is C14H16N2O2, and the molecular weight is 244.29 g/mol. InChIKey UXABARREKCJULM-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.