ISCK03 - 10mM in DMSO , CAS No.945526-43-2

CAS: 945526-43-2 Cat. No.: I427041 Formule: C₁₉H₂₁N₃O₂S Poids moléculaire: 355.45 Numéro CE: 633-636-8

GRADE & PURITY 10mM in DMSO

Synonyms

SCF/c-Kit Signaling Inhibitor | C77268 | HMS3229P07 | AC-35800 | t-Butylphenyl imidazolylphenyl sulfonamide | (4-t-butylphenyl)-N-(4-imidazole-1-yl phenyl)sulfonamide | N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide | HY-101443 | NCGC0038

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

Synonymes

SCF/c-Kit Signaling Inhibitor | C77268 | HMS3229P07 | AC-35800 | t-Butylphenyl imidazolylphenyl sulfonamide | (4-t-butylphenyl)-N-(4-imidazole-1-yl phenyl)sulfonamide | N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide | HY-101443 | NCGC0038

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Cell-permeable, selective SCF/c-Kit inhibitor (IC 50 < 2.5 μM). Blocks SCF-induced c-kit and Erk phosphorylation without affecting HGF-induced Erk phosphorylation. Shows antiangiogenic effects. Abolishes melanin production in vivo. ISCK03 inhibits in vitr

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Pubchem Sid: 528764915
• Sourires canoniques: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
• IUPAC Name: 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
• InChIKey: XQABBHBFHWHMKF-UHFFFAOYSA-N
• INCHI: 1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
• Isomères SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
• Poids moléculaire: 355.45
• Reaxy-Rn: 11120520
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11120520&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Imidazoles
        • Level5 Substituted imidazoles
          • Level6 Phenylimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Substituted imidazoles
• Direct Parent: Phenylimidazoles
• Alternative Parents: Sulfanilides Benzenesulfonamides Phenylpropanes Benzenesulfonyl compounds Organosulfonamides N-substituted imidazoles Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 1-phenylimidazole - Benzenesulfonamide - Sulfanilide - Benzenesulfonyl group - Phenylpropane - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Organosulfonic acid amide - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriétés chimiques et physiques

• Sensibilité: light sensitive
• Poids moléculaire: 355.500 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 355.135 Da
• Monoisotopic Mass: 355.135 Da
• Topological Polar Surface Area: 72.400 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 522.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1