Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 32 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.
An inhibitor of Cox-1 and Cox-2.
| ALogP | 3.1 |
|---|
| Pubchem Sid | 488179798 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179798 |
| Canonical Smiles | CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O |
| IUPAC Name | 2-(3-benzoylphenyl)propanoic acid |
| InChIKey | DKYWVDODHFEZIM-UHFFFAOYSA-N |
| INCHI | 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) |
| Isomeric SMILES | CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O |
| WGK Germany | 3 |
| RTECS | UE7570000 |
| Molecular Weight | 254.28 |
| Reaxy-Rn | 2216071 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2216071&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Benzophenones |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzophenones |
| Alternative Parents | Diphenylmethanes Aryl-phenylketones Phenylpropanoic acids Benzoyl derivatives Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Benzophenone - Aryl-phenylketone - Diphenylmethane - 2-phenylpropanoic-acid - Benzoyl - Aryl ketone - Ketone - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organooxygen compound - Organic oxide - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups. |
| External Descriptors | benzophenones - oxo monocarboxylic acid |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 21, 2026 | K129331 | |
| Certificate of Analysis | Dec 08, 2025 | K129331 | |
| Certificate of Analysis | Dec 16, 2024 | K129331 | |
| Certificate of Analysis | Dec 16, 2024 | K129331 | |
| Certificate of Analysis | Dec 05, 2024 | K129331 | |
| Certificate of Analysis | Dec 05, 2024 | K129331 | |
| Certificate of Analysis | Dec 05, 2024 | K129331 | |
| Certificate of Analysis | Dec 05, 2024 | K129331 | |
| Certificate of Analysis | Jul 11, 2024 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 29, 2023 | K129331 | |
| Certificate of Analysis | May 10, 2023 | K129331 | |
| Certificate of Analysis | Dec 20, 2022 | K129331 | |
| Certificate of Analysis | Nov 11, 2022 | K129331 | |
| Certificate of Analysis | Oct 17, 2022 | K129331 | |
| Certificate of Analysis | Jul 13, 2022 | K129331 |
| Solubility | Soluble in ethanol (51 mg/ml at 25 °C), DMSO (51 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), DMF (≥20 mg/ml), and PBS (pH 7.2) (≥0.5 mg/ml). |
|---|---|
| Sensitivity | Light sensitive |
| Melt Point(°C) | 92-97° |
| Molecular Weight | 254.280 g/mol |
| XLogP3 | 3.100 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 254.094 Da |
| Monoisotopic Mass | 254.094 Da |
| Topological Polar Surface Area | 54.400 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 331.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2023) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:38072270] [10.1016/j.scitotenv.2023.169170] |
| 2. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, [PMID:37806085] [10.1016/j.biopha.2023.115641] |
| 3. Mei Zhang, Yizhong Yuan, Jie Jin, Jinyu Sun, Xiaohui Tian. (2023) Polyvinyl alcohol composite hydrogels/epoxidized natural rubber composites (CMCS/PVA/CS-ENR) with core-shell structure as biomass coating material for slow-release nitrogen fertilizer. PROGRESS IN ORGANIC COATINGS, [PMID:] [10.1016/j.porgcoat.2023.107744] |
| 4. Pengzhao Han, Kai Hu, Yuanpeng Wang, Lixin Li, Pan Wang, Weixia Zhu, Haiyan Gong, Zhenqiang Zhang, Shusheng Zhang. (2022) Dispersive solid-phase extraction of non-steroidal anti-inflammatory drugs in water and urine samples using a magnetic ionic liquid hypercrosslinked polymer composite. JOURNAL OF CHROMATOGRAPHY A, [PMID:36586287] [10.1016/j.chroma.2022.463745] |
| 5. Hao-Ze Li, Cheng Yang, Hai-Long Qian, Xiu-Ping Yan. (2022) Room-temperature synthesis of ionic covalent organic frameworks for efficient removal of diclofenac sodium from aqueous solution. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2022.122704] |
| 6. Jinbo Ouyang, Jian Chen, Wenqian Chen, Limin Zhou, Di Cai, Cong Ren. (2022) H3PO4 activated biochars derived from different agricultural biomasses for the removal of ciprofloxacin from aqueous solution. Particuology, [PMID:] [10.1016/j.partic.2022.07.016] |
| 7. Yuemei Cen, Haihang Wang, Ping Wen, Genying Xu, Feng Tian, Fenggang Bian, Xiangqiong Zeng. (2022) The development of an artificial skin membrane mimicking the lipid bilayer structure for in vitro permeation study. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [PMID:] [10.1016/j.colsurfa.2022.128609] |
| 8. Lixiao Wang, Yajie Zheng, Yiran Zhou, Junhe Lu, Jean-Marc Chovelon, Yuefei Ji. (2021) Aquatic photolysis of ketoprofen generates products with photosensitizing activity and toxicity. WATER RESEARCH, [PMID:34954366] [10.1016/j.watres.2021.117982] |
| 9. Jian Chen, Jinbo Ouyang, Wenqian Chen, Zepeng Zheng, Zhen Yang, Zhirong Liu, Limin Zhou. (2021) Fabrication and adsorption mechanism of chitosan/Zr-MOF (UiO-66) composite foams for efficient removal of ketoprofen from aqueous solution. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2021.134045] |
| 10. Ying Lu, Fujian Yang, Siyuan Chen, Wenchao Shi, Chengdu Qi, Guilong Peng. (2021) Decomplexation of Ni(II)-citrate and recovery of nickel from chelated nickel containing electroplating wastewater by peroxymonosulfate with nickel. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2021.120142] |
| 11. Jian Chen, Jinbo Ouyang, Weixin Lai, Xiaohong Xing, Limin Zhou, Zhirong Liu, Wenqian Chen, Di Cai. (2021) Synthesis of ultralight chitosan/activated biochar composite aerogel globules for ketoprofen removal from aqueous solution. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2021.119700] |
| 12. Shan Chen, Shu Zhou, Jinli Fu, Sisi Tang, Xiaodan Wu, Pengfei Zhao, Zhaohui Zhang. (2021) A near infrared fluorescence imprinted sensor based on zinc oxide nanorods for rapid determination of ketoprofen. Analytical Methods, 13 (25): (2836-2846). [PMID:34080589] [10.1039/D1AY00555C] |
| 13. Xu Xu, Feng Xue, Liu Zhen, Xue Shan, Zhang Lei. (2021) 3D flower-liked Fe3O4/C for highly sensitive magnetic dispersive solid-phase extraction of four trace non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 188 (2): (1-10). [PMID:33496871] [10.1007/s00604-021-04708-1] |
| 14. Qian Han, Cun Wang, Pingkun Liu, Gui Zhang, Li Song, Yingzi Fu. (2021) Achieving synergistically enhanced dual-mode electrochemiluminescent and electrochemical drug sensors via a multi-effect porphyrin-based metal-organic framework. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2020.129388] |
| 15. Yixian Zhou, Boyi Niu, Biyuan Wu, Sulan Luo, Jintao Fu, Yiting Zhao, Guilan Quan, Xin Pan, Chuanbin Wu. (2020) A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility. Acta Pharmaceutica Sinica B, [PMID:33354510] [10.1016/j.apsb.2020.07.018] |
| 16. Tiemei Li, Yuefei Song, Zhaoqi Dong, Yueyue Shi, Jing Fan. (2020) Hydrophobic deep eutectic solvents as extractants for the determination of bisphenols from food-contacted plastics by high performance liquid chromatography with fluorescence detection. JOURNAL OF CHROMATOGRAPHY A, [PMID:32327226] [10.1016/j.chroma.2020.461087] |
| 17. Guanqiong Na, Xiaofei Hu, Yaning Sun, Guangxu Xing, Yunrui Xing, Gaiping Zhang. (2020) A novel gold particle-based paper sensor for sensitively detecting carprofen in bovine muscle. FOOD AND AGRICULTURAL IMMUNOLOGY, [PMID:] [10.1080/09540105.2020.1740178] |
| 18. Yixian Zhou, Sulan Luo, Boyi Niu, Biyuan Wu, Jintao Fu, Yiting Zhao, Vikramjeet Singh, Chao Lu, Guilan Quan, Xin Pan, Jiwen Zhang, Chuanbin Wu. (2019) Ultramild One-Step Encapsulating Method as a Modular Strategy for Protecting Humidity-Susceptible Metal–Organic Frameworks Achieving Tunable Drug Release Profiles. ACS Biomaterials Science & Engineering, [PMID:33455224] [10.1021/acsbiomaterials.9b01233] |
| 19. Tong Wang, Hai-Long Wu, Yong-Jie Yu, Wan-Jun Long, Li Cheng, An-Qi Chen, Ru-Qin Yu. (2019) A simple method for direct modeling of second-order liquid chromatographic data with retention time shifts and holding the second-order advantage. JOURNAL OF CHROMATOGRAPHY A, [PMID:31326090] [10.1016/j.chroma.2019.07.014] |
| 20. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
| 21. Wang Xiaobing, Zhu Huijuan, Shi Xiuyi, Qiu Xiuzhen, Lu Wenguan, Guo Huishi. (2019) Synthesis of MOF-199/CNTs Nanocomposite for Selective Adsorption and Determination of Nonsteroidal Anti-Inflammatory Drugs in Human Urine. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 19 (2): (627-633). [PMID:30360133] [10.1166/jnn.2019.15733] |
| 22. Na Li, Juan Chen, Yan-Ping Shi. (2018) Magnetic polyethyleneimine functionalized reduced graphene oxide as a novel magnetic sorbent for the separation of polar non-steroidal anti-inflammatory drugs in waters. TALANTA, [PMID:30262094] [10.1016/j.talanta.2018.09.006] |
| 23. Yue Zhai, Xue Bai, Jinyang Zhu, Xueke Sun, Gencai Pan, Biao Dong, Lin Xu, Wen Xu, Shuang Zhang, Hongwei Song. (2018) Luminescence carbon dot-based nanofibers for a water-insoluble drug release system and their monitoring of drug release. Journal of Materials Chemistry B, 6 (21): (3579-3585). [PMID:32254453] [10.1039/C8TB00117K] |
| 24. Xuemei Wang, Wei Zhou, Chenlu Wang, Zilin Chen. (2018) Cotton fiber-supported layered double hydroxides for the highly efficient adsorption of anionic organic pollutants in water. NEW JOURNAL OF CHEMISTRY, 42 (12): (9463-9471). [PMID:] [10.1039/C8NJ00678D] |
| 25. Wang Tong, Wu Hai-Long, Xie Li-Xia, Liu Zhi, Long Wan-Jun, Cheng Li, Ding Yu-Jie, Yu Ru-Qin. (2018) Simultaneous and interference-free determination of eleven non-steroidal anti-inflammatory drugs illegally added into Chinese patent drugs using chemometrics-assisted HPLC-DAD strategy. Science China-Chemistry, 61 (6): (739-749). [PMID:] [10.1007/s11426-017-9210-8] |
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