KN-93 - Moligand™, 10mM in DMSO , Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit, CAS No.139298-40-1, Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

CAS: 139298-40-1 Cat. No.: K421478 Formule: C₂₆H₂₉ClN₂O₄S Poids moléculaire: 599.03

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
An effective inhibitor of CaMKII phosphorylating activity

Specifications

Synonymes

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to i

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

Noms et identifiants

• Isomères SMILES: CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
• WGK Allemagne: 3
• Poids moléculaire: 599.03
• Reaxy-Rn: 8357363
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8357363&ln=

Cibles associées (humaines)

CAMK2A Tchem Calcium/calmodulin-dependent protein kinase type II subunit alpha (1 Activities)

Discover Target: CAMK2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Sensibilité: Heat Sensitive
• Indice de réfraction: 1.63
• Point d'ébullition (°C): 657.60° C at 760 mmHg

Références

1. Jinpeng Lv, Ximei Zhang, Xiaohong An, Yan Cao, Duo Meng, Kun Zou, Rongyin Gao, Ruzhi Zhang.  (2023)  The inhibition of VDAC1 oligomerization promotes pigmentation through the CaMK–CRTCs/CREB–MITF pathway.  EXPERIMENTAL CELL RESEARCH,      [PMID:38070860] [10.1016/j.yexcr.2023.113874]

2. Yuqian Chen, Jin Liu, Qianqian Zhang, Limin Chai, Huan Chen, Danyang Li, Yan Wang, Yuanjie Qiu, Nirui Shen, Jia Zhang, Qingting Wang, Jian Wang, Xinming Xie, Shaojun Li, Manxiang Li.  (2024)  Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:38479721] [10.1016/j.ejphar.2024.176483]