Koumine - ≥98% , CAS No.1358-76-5

CAS: 1358-76-5 Cat. No.: K418590 Formule: C₂₀H₂₂N₂O Poids moléculaire: 306.4 Numéro CE: 111-893-2

GRADE & PURITY ≥98%

Synonyms

(3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4 | CID 91895267

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Koumine can induce apoptosis of LoVo cells in a time-dependent manner and inhibit the DNA synthesis in LoVo cells, thereby blocking the cell cycle from G1 to S phase. Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has therapeutic effect against psoriasis, which is related to the inhibition of epidermal cell proliferation, promoting the formation of granular cells and decreasing the serum level of IL- Koumine can significantly reduce the damage to axon and myelin sheath of the sciatic nerve and increase sensory nerve conduction velocity , without affecting body weight and blood glucose, these findings encourage the use of koumine in the treatment of diabetic neuropathy. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. Koumine may produce anxiolytic-effect by increasing the levels of pregnenolone and allopregnenolone in hippocampus.

Specifications

Synonymes

(3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4 | CID 91895267

Spécifications et pureté

≥98%

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Propriétés du produit

• ALogP: 1.879
• hba_count: 2
• Liaison rotative: 1

Noms et identifiants

• Pubchem Sid: 488202539
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202539
• Sourires canoniques: CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C
• IUPAC Name: (1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene
• InChIKey: VTLYEMHGPMGUOT-FXWNUWCSSA-N
• INCHI: 1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1
• Isomères SMILES: CN1C[C@]2([C@@H]3C[C@@H]4C5=NC6=CC=CC=C6[C@]52C[C@H]1[C@H]3CO4)C=C
• Poids moléculaire: 306.4
• Reaxy-Rn: 25328208
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328208&ln=

Propriétés chimiques et physiques

• Solubilité: DMSO: 2 mg/mL, clear (Warmed)
• Sensibilité: Light sensitive;Moisture sensitive
• DMSO (mg/mL) Solubilité maximale: 15
• DMSO (mM) Solubilité maximale: 48.9553771084918

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1358-76-5, the molecular formula is C20H22N2O, and the molecular weight is 306.4 g/mol. InChIKey VTLYEMHGPMGUOT-FXWNUWCSSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.