LDN 212320 - ≥98%(HPLC) , CAS No.894002-50-7

CAS: 894002-50-7 Cat. No.: L287431 Formule: C₁₇H₁₅N₃S Poids moléculaire: 293.39

GRADE & PURITY ≥98%(HPLC)

Synonyms

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine | LDN-212320 | LDN/OSU-0212320, LDN-0212320, OSU-0212320 | 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonymes

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine | LDN-212320 | LDN/OSU-0212320, LDN-0212320, OSU-0212320 | 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine

Spécifications et pureté

≥98%(HPLC)

Mécanismes biochimiques et physiologiques

Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activityin vivo.Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ACTIVATOR

Pureté

≥98%(HPLC)

Noms et identifiants

• Pubchem Sid: 504764734
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764734
• Sourires canoniques: CC1=CC=CC=C1CSC2=NN=C(C=C2)C3=CC=CC=N3
• IUPAC Name: 3-[(2-methylphenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine
• InChIKey: DUUQLWDHNYFUPP-UHFFFAOYSA-N
• INCHI: 1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3
• Isomères SMILES: CC1=CC=CC=C1CSC2=NN=C(C=C2)C3=CC=CC=N3
• Poids moléculaire: 293.39
• Reaxy-Rn: 21840389
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21840389&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazines
      • Subclass Pyrimidines and pyrimidine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazines
• Subclass: Pyrimidines and pyrimidine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinylpyrimidines
• Alternative Parents: Toluenes Alkylarylthioethers Pyridines and derivatives Pyridazines and derivatives Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridinylpyrimidine - Aryl thioether - Toluene - Alkylarylthioether - Monocyclic benzene moiety - Pyridazine - Pyridine - Benzenoid - Heteroaromatic compound - Thioether - Sulfenyl compound - Azacycle - Hydrocarbon derivative - Organic nitrogen compound - Organonitrogen compound - Organosulfur compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyridinylpyrimidines. These are compounds containing a pyridinylpyrimidine skeleton, which consists of a pyridine linked (not fused) to a pyrimidine by a bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (non humaines)

Slc1a2 Excitatory amino acid transporter 2 (39 Activities)

Discover Target: Slc1a2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solvent:DMSO, Max Conc. mg/mL: 29.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 5.87, Max Conc. mM: 20
• Poids moléculaire: 293.400 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 293.099 Da
• Monoisotopic Mass: 293.099 Da
• Topological Polar Surface Area: 64.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 312.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 894002-50-7, the molecular formula is C17H15N3S, and the molecular weight is 293.39 g/mol. InChIKey DUUQLWDHNYFUPP-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.