Leriglitazone , Peroxisome proliferator-activated receptor gamma agonist, CAS No.146062-44-4, Peroxisome proliferator-activated receptor gamma agonist

CAS: 146062-44-4 Cat. No.: L646421 Formule: C19H20N2O4S Poids moléculaire: 372.44
DISPONIBLE À COMMANDE
Synonyms
WHO 10868 | ALL-AMBO-5-((4-(2-(5-(1-HYDROXYETHYL)PYRIDIN-2-YL)ETHOXY)PHENYL)METHYL)-1,3-THIAZOLE-2,4(3H,5H)-DIONE | 5-(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione | BDBM50530214 | LERIGLITAZONE [INN] | Leriglitazone (USA
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Size
Allemagne (EU)
USA*
Price
Qty
5mg
L646421-5mg
Sur commande · 8–12 semaines
1 076,78€
10mg
L646421-10mg
Sur commande · 8–12 semaines
1 701,55€
Enter a quantity for the sizes you want to add.
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Why this grade

for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Vue d’ensemble

Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with a K i of 1.2 μM,Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC 50 of 680 nM

Form:Solid

IC50& Target:Ki: 1.2 μM (PPARγ LBD),EC: 680 nM (PPARγ LBD) (Leriglitazone)

Specifications

Synonymes
WHO 10868 | ALL-AMBO-5-((4-(2-(5-(1-HYDROXYETHYL)PYRIDIN-2-YL)ETHOXY)PHENYL)METHYL)-1,3-THIAZOLE-2,4(3H,5H)-DIONE | 5-(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione | BDBM50530214 | LERIGLITAZONE [INN] | Leriglitazone (USA
Mécanismes biochimiques et physiologiques
Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.\nLeriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording s
Conditions de stockage de stockage
Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Type d'action
AGONIST
Mécanisme d'action
Peroxisome proliferator-activated receptor gamma agonist
Propriétés du produit
ALogP
2.5
Noms et identifiants
Sourires canoniques
CC(C1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)O
IUPAC Name
5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
InChIKey
OXVFDZYQLGRLCD-UHFFFAOYSA-N
INCHI
1S/C19H20N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24)
Isomères SMILES
CC(C1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)O
CAS alternatif
146062-44-4
Termes d'entrée MeSH
leriglitazone
Poids moléculaire
372.44
Reaxy-Rn
7493230
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7493230&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassePhenol ethers
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentPhenol ethers
Alternative Parents Phenoxy compounds  Alkyl aryl ethers  Thiazolidinediones  Pyridines and derivatives  Dicarboximides  Heteroaromatic compounds  Organic carbonic acids and derivatives  Thiocarbamic acid derivatives  Secondary alcohols  Azacyclic compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Aromatic alcohols  Carbonyl compounds  Organopnictogen compounds  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Phenoxy compound - Phenol ether - Alkyl aryl ether - Thiazolidinedione - Monocyclic benzene moiety - Pyridine - Dicarboximide - Heteroaromatic compound - Thiazolidine - Carbonic acid derivative - Secondary alcohol - Thiocarbamic acid derivative - Azacycle - Ether - Carboxylic acid derivative - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Alcohol - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Aromatic alcohol - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
External Descriptors aromatic ether - pyridines - thiazolidenediones
Structure 3D
Modèle de structure chimique interactif





Cibles associées (humaines)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mécanismes d'action
Certificats (CoA, COO, BSE/TSE et tableau d'analyse)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propriétés chimiques et physiques
Poids moléculaire372.400 g/mol
XLogP32.500
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass372.114 Da
Monoisotopic Mass372.114 Da
Topological Polar Surface Area114.000 Ų
Heavy Atom Count26
Formal Charge0
Complexity496.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculateurs de solution
Avis

Avis des clients

Foire aux questions

How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 146062-44-4, the molecular formula is C19H20N2O4S, and the molecular weight is 372.44 g/mol. InChIKey OXVFDZYQLGRLCD-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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