LH846 - ≥98% , CAS No.639052-78-1

CAS: 639052-78-1 Cat. No.: L304252 Formule: C₁₆H₁₃ClN₂OS Poids moléculaire: 316.8 Numéro CE: 804-181-4

GRADE & PURITY ≥98%

Synonyms

N-(5-chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide | AKOS000461714 | BCP09669 | UNII-RW5ZBU2L6P | NCGC00371143-05 | LH846 | LH-846 | MFCD03786038 | N-(5-Chloro-6-methyl-benzothiazol-2-yl)-2-phenyl-acetamide | LH 846 | N-(5-Chloro-6-methyl-2-benzo

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonymes

N-(5-chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide | AKOS000461714 | BCP09669 | UNII-RW5ZBU2L6P | NCGC00371143-05 | LH846 | LH-846 | MFCD03786038 | N-(5-Chloro-6-methyl-benzothiazol-2-yl)-2-phenyl-acetamide | LH 846 | N-(5-Chloro-6-methyl-2-benzo

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Potent, selective CK1δ inhibitor (IC 50 values are 0.29, 1.3 and 2.5 μM for CK1δ, ε and α, respectively). Induces period lengthening of the circadian rhythm in U2OS cells.LH846 is a potent and selective inhibitor of the known clock regulatory kinase Casei

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureté

≥98%

Noms et identifiants

• Pubchem Sid: 504760262
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504760262
• Sourires canoniques: CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3
• IUPAC Name: N-(5-chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
• InChIKey: DYHAMRNAHTWYKY-UHFFFAOYSA-N
• INCHI: 1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)
• Isomères SMILES: CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3
• Poids moléculaire: 316.8
• Reaxy-Rn: 32136746
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32136746&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Phenylacetamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Phenylacetamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylacetamides
• Alternative Parents: Benzothiazoles N-arylamides Aryl chlorides Thiazoles Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylacetamide - 1,3-benzothiazole - N-arylamide - Aryl chloride - Aryl halide - Azole - Thiazole - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO: 50 mg/mL
• Sensibilité: light sensitive
• Poids moléculaire: 316.800 g/mol
• XLogP3: 4.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 316.044 Da
• Monoisotopic Mass: 316.044 Da
• Topological Polar Surface Area: 70.200 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 375.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 639052-78-1, the molecular formula is C16H13ClN2OS, and the molecular weight is 316.8 g/mol. InChIKey DYHAMRNAHTWYKY-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.