Lin28 1632 - ≥98%(HPLC) , CAS No.108825-65-6

CAS: 108825-65-6 Cat. No.: L287258 Formule: C₁₅H₁₅N₅O Poids moléculaire: 281.31

GRADE & PURITY ≥98%(HPLC)

Synonyms

Lin28 1632 | Lin-28 1632 | N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]-pyridazin-6-yl)phenyl]acetamide | N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide | CCG-42206 | DTXSID20371981 | HMS1448E05 | Lin281632 | Lin-281632 | WP

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Product Describtion:

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.

Specifications

Synonymes

Lin28 1632 | Lin-28 1632 | N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]-pyridazin-6-yl)phenyl]acetamide | N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide | CCG-42206 | DTXSID20371981 | HMS1448E05 | Lin281632 | Lin-281632 | WP

Spécifications et pureté

≥98%(HPLC)

Mécanismes biochimiques et physiologiques

RNA binding protein Lin28 inhibitor (IC50= 8μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Increaseslet-7miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Inhibit

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Pureté

≥98%(HPLC)

Noms et identifiants

• Pubchem Sid: 488192879
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488192879
• Sourires canoniques: CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
• IUPAC Name: N-methyl-N-[3-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
• InChIKey: WPAQLESUVYGUJZ-UHFFFAOYSA-N
• INCHI: 1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3
• Isomères SMILES: CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
• Poids moléculaire: 281.31
• Reaxy-Rn: 13479104
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13479104&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazines
      • Subclass Pyridazines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazines
• Subclass: Pyridazines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridazines
• Alternative Parents: Acetanilides Triazolopyridazines Triazoles Tertiary carboxylic acid amides Heteroaromatic compounds Acetamides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylpyridazine - Acetanilide - Triazolopyridazine - Anilide - Monocyclic benzene moiety - Benzenoid - Azole - Tertiary carboxylic acid amide - 1,2,4-triazole - Acetamide - Heteroaromatic compound - Carboxamide group - Carboxylic acid derivative - Azacycle - Organopnictogen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpyridazines. These are organic compounds containing a pyridazine ring substituted by a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

Discover Target: BRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Solvent:DMSO, Max Conc. mg/mL: 28.13, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 28.13, Max Conc. mM: 100
• Poids moléculaire: 281.310 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 281.128 Da
• Monoisotopic Mass: 281.128 Da
• Topological Polar Surface Area: 63.400 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 390.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1