Losartan - Moligand™, 10mM in DMSO , Antagonist of AT 1 receptor, CAS No.114798-26-4, Antagonist of AT 1 receptor

CAS: 114798-26-4 Cat. No.: L420721 Formule: C₂₂H₂₃ClN₆O Poids moléculaire: 422.92 Numéro CE: 601-329-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

losartan|114798-26-4|DUP 89|allisartan|Angizaar|Losartic|Hyzaar|Cozaar|Lozap|LOSARTAN POTASSIUM|CHEBI:6541|DUP-89|DTXSID7023227|UNII-JMS50MPO89|JMS50MPO89|Losartan (INN)|NSC-758699|HGP1405|HGP-1405|DuP-753|(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphen

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Losartan is a potent, non-peptide antagonist of angiotensin II receptor, type 1 (AT1). This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II.

Specifications

Synonymes

losartan | 114798-26-4 | DUP 89 | allisartan | Angizaar | Losartic | Hyzaar | Cozaar | Lozap | LOSARTAN POTASSIUM | CHEBI:6541 | DUP-89 | DTXSID7023227 | UNII-JMS50MPO89 | JMS50MPO89 | Losartan (INN) | NSC-758699 | HGP1405 | HGP-1405 | DuP-753 | (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphen

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

Losartan is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan is used for treatment of hypertension.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ANTAGONIST

Mécanisme d'action

Antagonist of AT 1 receptor

Noms et identifiants

Pubchem Sid

528772930

Sourires canoniques

CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl

IUPAC Name

[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol

InChIKey

PSIFNNKUMBGKDQ-UHFFFAOYSA-N

INCHI

1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

Isomères SMILES

CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl

CAS alternatif

114798-26-4,124750-99-8 (mono-potassium salt)

Numéro NSC

758699

Termes d'entrée MeSH

2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol;Cozaar;DuP 753;DuP-753;DuP753;Losartan;Losartan Monopotassium Salt;Losartan Potassium;MK 954;MK-954;MK954;Monopotassium Salt, Losartan;Potassium, Losartan;Salt,

Poids moléculaire

422.92

Reaxy-Rn

4828951

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4828951&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Phenyltetrazoles and derivatives 1,2,4,5-tetrasubstituted imidazoles N-substituted imidazoles Aryl chlorides Heteroaromatic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Organochlorides Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Biphenyl - Phenyltetrazole - 1,2,4,5-tetrasubstituted imidazole - Aryl chloride - Aryl halide - N-substituted imidazole - Azole - Heteroaromatic compound - Imidazole - Tetrazole - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic alcohol - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Primary alcohol - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: imidazoles - biphenylyltetrazole

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme (0 Activities)

Discover Target: ACE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor (0 Activities)

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR2 Tchem Type-2 angiotensin II receptor (0 Activities)

Discover Target: AGTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Point de fusion (°C): 183.5-184.5° C
• Poids moléculaire: 422.900 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 422.162 Da
• Monoisotopic Mass: 422.162 Da
• Topological Polar Surface Area: 92.500 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 520.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1