Lp-PLA2-IN-3 - 10mM in DMSO , CAS No.2196245-16-4

CAS: 2196245-16-4 Cat. No.: L656603 Formule: C₂₀H₁₃ClF₃N₃O₃S Poids moléculaire: 467.85 PubChem CID: 132427687

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC 50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2).

In Vivo

Lp-PLA2-IN-3 (3 mg/kg; p.o.) treatment shows the C max , AUC 0-24h , t 1/2 and F were 0.27 μg/mL, 3.4 μg h/mL, 7.7 hours and 35.5%, respectively . Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t 1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague−Dawley (SD) rats (180-220 g) Dosage: 3 mg/kg Administration: p.o. (Pharmacokinetic Analysis) Result: The C max , AUC 0-24h , t 1/2 and F were 0.27 μg/mL, 6.2 μg h/mL, 7.7 hours and 35.5%, respectively.

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC 50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2).

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Isomères SMILES: C1=CC(=CC=C1N)S(=O)(=O)NC2=CC(=C(C=C2)OC3=CC(=C(C=C3)Cl)C(F)(F)F)C#N
• PubChem CID: 132427687
• Poids moléculaire: 467.85

Cibles associées (humaines)

PLA2G7 Tchem Platelet-activating factor acetylhydrolase (0 Activities)

Discover Target: PLA2G7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2196245-16-4, the molecular formula is C20H13ClF3N3O3S, and the molecular weight is 467.85 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.