Velzatinib(M4205) - Moligand™,≥99% , CAS No.2590556-80-0

CAS: 2590556-80-0 Cat. No.: M650715 Formule: C₂₉H₃₂N₈O Poids moléculaire: 508.62 PubChem CID: 155587867

QUALITÉ & PURETÉ Moligand™, ≥99%

Synonyms

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

M4205 is a c-KIT inhibitor, with an IC 50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.

Form:Solid

IC50& Target:c-KIT

Spécifications

Synonymes

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine | MS-29449 | compound 32 [PMID: 36728508] | K3R | M4205 | M-4205 | Y6UHU32G5Z | GTPL11510 | 4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyra

Spécifications et pureté

Moligand™,≥99%

Mécanismes biochimiques et physiologiques

Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

Sourires canoniques

CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6

IUPAC Name

N-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine

InChIKey

LVMAULGVWBINFP-UHFFFAOYSA-N

INCHI

1S/C29H32N8O/c1-35-20-24(18-34-35)23-7-5-22(6-8-23)17-30-28-16-26(32-21-33-28)27-19-31-29-15-25(9-13-37(27)29)38-14-4-12-36-10-2-3-11-36/h5-9,13,15-16,18-21H,2-4,10-12,14,17H2,1H3,(H,30,32,33)

Isomères SMILES

CN1C=C(C=N1)C2=CC=C(C=C2)CNC3=NC=NC(=C3)C4=CN=C5N4C=CC(=C5)OCCCN6CCCC6

CAS alternatif

2590556-80-0

PubChem CID

155587867

Poids moléculaire

508.62

Propriétés chimiques et physiques

• Solubilité: DMSO : 11.11 mg/mL (21.84 mM; ultrasonic and warming and heat to 66°C)
• Poids moléculaire: 508.600 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 508.27 Da
• Monoisotopic Mass: 508.27 Da
• Topological Polar Surface Area: 85.400 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 715.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2590556-80-0, the molecular formula is C29H32N8O, and the molecular weight is 508.62 g/mol. InChIKey LVMAULGVWBINFP-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.