Magnolol - 10mM in DMSO , CAS No.528-43-8

CAS: 528-43-8 Cat. No.: M407956 Formule: C₁₈H₁₈O₂ Poids moléculaire: 266.33 Beilstein Registry Number: 6(4)6918 Numéro CE: 610-903-7

GRADE & PURITY 10mM in DMSO

Synonyms

NSC 293099 | [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Magnolol Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.
In vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABA_A receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

In vivo

LD50: Mice 2200mg/kg (i.g.).
Cell Data

cell lines：LNCaP/AR prostate cancer cell line

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonymes

NSC 293099 | [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

Isomères SMILES

C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

WGK Allemagne

3

RTECS

DV5105500

Numéro ONU

3077

Poids moléculaire

266.33

Beilstein

6(4)6918

Reaxy-Rn

1982224

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1982224&ln=

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro DMSO: 100 mg/mL (148.9 mM); Ethanol: 4 mg/mL (5.95 mM); Water: Insoluble
• Point d'ébullition (°C): 180 °C/1 mmHg
• Point de fusion (°C): 101 °C

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 528-43-8, the molecular formula is C18H18O2, and the molecular weight is 266.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.