Melittin, CAS No.37231-28-0

CAS: 37231-28-0 Cat. No.: M329573 Formule: C₁₃1H₂₂₉N₃₉O₃₁•x(C₂HF₃O₂) Poids moléculaire: 2846.46 + x(114.02) Numéro CE: 253-417-7 PubChem CID: 16129627

GRADE & PURITY ≥97%

Vue d’ensemble

Melittin, an antibacterial originally derived from|Apis mellifera|, has been reported to cause apoptosis via induction of reactive oxygen species production in cells. Additionally, this compound has been found to suppress 4α-Phorbol 12-myristate 13-acetate induced invasion of proliferative cells via inhibition of activator protein-1 and NF-κB. Other experiments show Melittin to be able to also suppress PMA-induced phosphorylation of ERK and JNK mitogen-activated protein kinases. This compound also activates phospholipase A2 (PLA2).

Specifications

Product Name

Melittin, CAS No.37231-28-0

Synonymes

Melittin | Q424512 | DTXSID40893812 | L-Glutamamide, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-Leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl

Spécifications et pureté

≥97%

Séquence

Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2

Source

Synthetic

CAS

37231-28-0

Type de molécule

Peptide

Stockage et expédition

Conditions de stockage de stockage

Store at -20°C,Argon charged

Expédié en

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic Polymers
    • Classe Polypeptides

• Kingdom: Organic compounds
• Superclass: Organic Polymers
• Classe: Polypeptides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Polypeptides
• Alternative Parents: Peptides Arginine and derivatives Glutamine and derivatives Isoleucine and derivatives Leucine and derivatives Valine and derivatives Proline and derivatives N-acyl-alpha amino acids and derivatives Tryptamines and derivatives Serine and derivatives Alpha amino acid amides Alanine and derivatives 3-alkylindoles Pyrrolidinecarboxamides N-acylpyrrolidines N-acyl amines Substituted pyrroles Benzenoids Heteroaromatic compounds Tertiary carboxylic acid amides Secondary carboxylic acid amides Primary carboxylic acid amides Secondary alcohols Guanidines Azacyclic compounds Carboximidamides Hydrocarbon derivatives Monoalkylamines Imines Primary alcohols Carbonyl compounds Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Polypeptide - Alpha peptide - Arginine or derivatives - Glutamine or derivatives - Isoleucine or derivatives - Leucine or derivatives - N-acyl-alpha amino acid or derivatives - Valine or derivatives - Proline or derivatives - Alpha-amino acid amide - Serine or derivatives - Triptan - Alanine or derivatives - Alpha-amino acid or derivatives - 3-alkylindole - N-substituted-alpha-amino acid - Indole - Indole or derivatives - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Substituted pyrrole - Benzenoid - Fatty amide - N-acyl-amine - Fatty acyl - Tertiary carboxylic acid amide - Pyrrolidine - Heteroaromatic compound - Pyrrole - Secondary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Secondary alcohol - Guanidine - Primary carboxylic acid amide - Azacycle - Carboximidamide - Organoheterocyclic compound - Carboxylic acid derivative - Primary amine - Hydrocarbon derivative - Imine - Amine - Organic oxide - Organic oxygen compound - Primary aliphatic amine - Carbonyl group - Alcohol - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Primary alcohol - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
• External Descriptors: Peptides

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Références

1. Weibin Zhang, Zhe An, Yuqi Bai, Ying Zhou, Fangyi Chen, Ke-Jian Wang.  (2023)  A novel antimicrobial peptide Scyreptin1-30 from Scylla paramamosain exhibiting potential therapy of Pseudomonas aeruginosa early infection in a mouse burn wound model.  BIOCHEMICAL PHARMACOLOGY,      [PMID:37952897] [10.1016/j.bcp.2023.115917]

2. Fenfang Liu, Fen Chen, Le Yang, Fucheng Qiu, Guangen Zhong, Shan Gao, Weizhe Xi, Meilian Lai, Qiting He, Ying Chen, Weiming Chen, Jiping Zhang, Lu Yang.  (2023)  Melittin acupoint injection in attenuating bone erosion in collagen-induced arthritis mice via inhibition of the RANKL/NF-κB signaling pathway.  Quantitative Imaging in Medicine and Surgery,      [PMID:37711782] [10.21037/qims-23-254]

3. Li Li, Sufang Zhang, Lei Wei, Zhongfu Wang, Wei Ma, Fangying Liu, Yanhua Shen, Shanfang Zhang, Xiulian Zhang, Yu Hang, Yechang Qian.  (2020)  Anti-fibrotic effect of melittin on TRIM47 expression in human embryonic lung fibroblast through regulating TRIM47 pathway.  LIFE SCIENCES,      [PMID:32502539] [10.1016/j.lfs.2020.117893]

4. Liu Lei, Liu Jie, Cui Qi, Jia Bo-Yan, Pei Zhi-Hua, Odah Kokou Ayefounin, Wang Yi-Ming, Dong Wen-Long, Kong Ling-Cong, Ma Hong-Xia.  (2019)  Design and Characterization of a Novel Hybrid Antimicrobial Peptide OM19R Based on Oncocin and MDAP-2.  International Journal of Peptide Research and Therapeutics,  26  (4): (1839-1846).  [PMID:] [10.1007/s10989-019-09984-3]

5. Chenyue Qiu, Jinfa Ye, Lang Ke, Xingyuan Wei, Peiyu Wang, Yun Han, Xiaofei Wen, Gang Liu, Chengchao Chu.  (2025)  Virus-mimetic nanovesicle for the Hijacking- Integration-Vesicular amplification-Exocytosis treatment of ocular tumor.  Materials Today Advances,      [PMID:] [10.1016/j.mtadv.2025.100643]

6. Yinhui Qin, Na Zhang, Yan Yang, Yuetai Teng, Yinhu Wang, Weihong Niu.  (2025)  Development of marine-derived indole derivatives as novel antibacterial agents against gram-positive bacteria.  BIOORGANIC CHEMISTRY,      [PMID:41319447] [10.1016/j.bioorg.2025.109300]

7. Yihong Gao, Yinjia Luo, Zeting Wang, Shuhua Wei, Chunfu Wei, Xi Kong, Xiao Yue, Guanlin Wang, Chuanbin Wu, Ziyu Zhao, Wenhao Wang, Xuejuan Zhang.  (2026)  Nanodisrupter loaded nasal spray for membrane perturbation-assisted treatment of lung cancer brain metastases: A proof-of-concept in vitro study.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2026.108279]