Memantine Hydrochloride - ≥98% , Glutamate [NMDA] receptor negative allosteric modulator, CAS No.41100-52-1, Glutamate [NMDA] receptor negative allosteric modulator

CAS: 41100-52-1 Cat. No.: M107928 Formule: C₁₂H₂₁N·HCl Poids moléculaire: 215.76 Numéro CE: 255-219-6

GRADE & PURITY ≥98%

Synonyms

MEMANTINE HYDROCHLORIDE (USP-RS) | Memantine Accord | NMI-131 | 3,5-dimethyladamantan-1-amine;hydrochloride | Axura | EINECS 255-219-6 | NCGC00262963-01 | 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride | AMY40819 | SMR000875213 | MLS0013326

Storage

Room temperature

Shipped In

Normal

Vue d’ensemble

Memantine hydrochloride has been used:

· as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity

· to intraperitoneally inject experimental animal to study its effect on traumatic injury

· as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration

Specifications

Synonymes

MEMANTINE HYDROCHLORIDE (USP-RS) | Memantine Accord | NMI-131 | 3,5-dimethyladamantan-1-amine;hydrochloride | Axura | EINECS 255-219-6 | NCGC00262963-01 | 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride | AMY40819 | SMR000875213 | MLS0013326

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Us

Conditions de stockage de stockage

Room temperature

Expédié en

Normal

Type d'action

NEGATIVE ALLOSTERIC MODULATOR

Mécanisme d'action

Glutamate [NMDA] receptor negative allosteric modulator

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureté

≥98%

Noms et identifiants

Pubchem Sid

488188516

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488188516

Sourires canoniques

CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

IUPAC Name

3,5-dimethyladamantan-1-amine;hydrochloride

InChIKey

LDDHMLJTFXJGPI-UHFFFAOYSA-N

INCHI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

Isomères SMILES

CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

WGK Allemagne

3

Poids moléculaire

215.76

Reaxy-Rn

6573843

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6573843&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Amines
        • Level5 Primary amines
          • Level6 Monoalkylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Primary amines
• Direct Parent: Monoalkylamines
• Alternative Parents: Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Primary aliphatic amine - Aliphatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

TRPV1 Tclin Vanilloid receptor (8273 Activities)

Discover Target: TRPV1

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A 172 (535 Activities)

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U-87 MG (3946 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

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GMNN Tbio Geminin (128009 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIN1 Tclin Glutamate NMDA receptor; GRIN1/GRIN2A (719 Activities)

Discover Target: GRIN1

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

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Cibles associées (non humaines)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Rattus norvegicus (775804 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

Discover Target: Npsr1

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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Grin1 Glutamate NMDA receptor; Grin1/Grin2b (1028 Activities)

Discover Target: Grin1

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Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: Soluble in water
• Point de fusion (°C): 292°C
• Poids moléculaire: 215.760 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 215.144 Da
• Monoisotopic Mass: 215.144 Da
• Topological Polar Surface Area: 26.000 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 240.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3