10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
MHY1485 MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy .
In vitro
MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥97%
| Isomères SMILES | C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4 |
|---|---|
| Poids moléculaire | 387.39 |
| Reaxy-Rn | 9952068 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9952068&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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| Lot Number | Certificate Type | Date | Article |
|---|---|---|---|
 I2402134 | Certificate of Analysis | Jul 02, 2026 | M408199 |
| Point de fusion (°C) | 259°C |
|---|
| 1. Wang Ping, Wang Min, Liu Lin, Li Hongyi, Liu Helin, Ren Jiangbo, Liu Tianhui, Cong Min, Zhu Zhijun, Zhao Xinyan, Sun Liying, Jia Jidong. (2024) Targeting NPM1 inhibits proliferation and promotes apoptosis of hepatic progenitor cells via suppression of mTOR signalling pathway. Stem Cell Research & Therapy, 15 (1): (1-15). [PMID:39256792] [10.1186/s13287-024-03898-8] |
| 2. Tian-Shuang Xia, Sheng-Yan Xu, Li-Yong Lai, Yi-Ping Jiang, Na-Ni Wang, Hai-Liang Xin. (2024) Bitter acids from Humulus lupulus L. alleviate D-galactose induced osteoblastic senescence and bone loss via regulating AKT/mTOR-mediated autophagy. JOURNAL OF FOOD AND DRUG ANALYSIS, 32 (4): (506). [PMID:39752859] [10.38212/2224-6614.3508] |
| 3. Yuchen Liu, Xue Tian, Cui Li, Jing Lin, Lina Zhang, Qian Wang, Hong Li, Yuqi Li, Xiangzhi Liu, Guiqiu Zhao. (2025) Artesunate Treats Aspergillus fumigatus Keratitis by Inhibiting Fungal Activity and Activating Autophagy Pathway to Reduce Corneal Inflammation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 66 (11): (19-19). [PMID:40772662] [10.1167/iovs.66.11.19] |
