Miransertib - Moligand™, 10mM in DMSO , Allosteric modulator of AKT serine/threonine kinase 1;Inhibitor of AKT serine/threonine kinase 1;Allosteric modulator of AKT serine/threonine kinase 2;Inhibitor of AKT serine/threonine kinase 2;Allosteric modulator , Allosteric modulator of AKT serine/threonine kinase 1;Inhibitor of AKT serine/threonine kinase 1;Allosteric modulator of AKT serine/threonine kinase 2;Inhibitor of AKT serine/threonine kinase 2;Allosteric modulator of AKT serine/threonine kinase 3;Inhibit

CAS: 1313881-70-7 Cat. No.: M421214 Formule: C₂₇H₂₄N₆ Poids moléculaire: 432.53 Numéro CE: 855-383-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1313881-70-7 | BDBM50593633 | D11409 | 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3HIMIDAZO(4,5-B)PYRIDIN-2-YL)PYRIDIN-2-AMINE | Miransertib [USAN] | T1DQI1B52Y | AI-942/25034199 | HY-19719 | (+/-) camphorsulfonic acid | ARQ 092 | F85345 | Miransertib [U

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.

Specifications

Synonymes

1313881-70-7 | BDBM50593633 | D11409 | 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3HIMIDAZO(4,5-B)PYRIDIN-2-YL)PYRIDIN-2-AMINE | Miransertib [USAN] | T1DQI1B52Y | AI-942/25034199 | HY-19719 | (+/-) camphorsulfonic acid | ARQ 092 | F85345 | Miransertib [U

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

Allosteric, selective, non-ATP competitive\xa0pan-Akt inhibitor (IC 50 = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). Selective for Akt isoforms over a panel of 303 other kinases.

Conditions de stockage de stockage

Protected from light,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ALLOSTERIC MODULATOR, INHIBITOR

Mécanisme d'action

Allosteric modulator of AKT serine/threonine kinase 1;Inhibitor of AKT serine/threonine kinase 1;Allosteric modulator of AKT serine/threonine kinase 2;Inhibitor of AKT serine/threonine kinase 2;Allosteric modulator of AKT serine/threonine kinase 3;Inhibit

Propriétés du produit

• ALogP: 3.8

Noms et identifiants

• Pubchem Sid: 528765632
• Sourires canoniques: C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
• IUPAC Name: 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
• InChIKey: HNFMVVHMKGFCMB-UHFFFAOYSA-N
• INCHI: 1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
• Isomères SMILES: C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N
• CAS alternatif: 1313881-70-7
• Termes d'entrée MeSH: 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo(4,5-b)pyridin-2-yl)pyridin-2-amine;ARQ 092;Miransertib
• Poids moléculaire: 432.53
• Reaxy-Rn: 21571033
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21571033&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Phenylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Phenylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridines
• Alternative Parents: Phenylimidazoles Imidazopyridines Aralkylamines Aminopyridines and derivatives N-substituted imidazoles Imidolactams Benzene and substituted derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 2-phenylpyridine - 1-phenylimidazole - Imidazopyridine - Aminopyridine - Aralkylamine - Imidolactam - Benzenoid - N-substituted imidazole - Monocyclic benzene moiety - Imidazole - Azole - Heteroaromatic compound - Azacycle - Amine - Primary amine - Hydrocarbon derivative - Organopnictogen compound - Organonitrogen compound - Primary aliphatic amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

AKT3 Tchem RAC-gamma serine/threonine-protein kinase (1 Activities)

Discover Target: AKT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT2 Tchem RAC-beta serine/threonine-protein kinase (1 Activities)

Discover Target: AKT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT1 Tchem RAC-alpha serine/threonine-protein kinase (1 Activities)

Discover Target: AKT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT2 Tchem Serine/threonine-protein kinase AKT2 (4301 Activities)

Discover Target: AKT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT3 Tchem Serine/threonine-protein kinase AKT3 (3157 Activities)

Discover Target: AKT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)

Discover Target: AKT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SW-620 (52400 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT1S1 Tchem Proline-rich AKT1 substrate 1 (25 Activities)

Discover Target: AKT1S1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Poids moléculaire: 432.500 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 432.206 Da
• Monoisotopic Mass: 432.206 Da
• Topological Polar Surface Area: 95.600 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 653.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Références

1. Ming Luo, Yawei Du, Xuanchen Liu, Shuwen Zhang, Wenwen Zhu, Kaipeng Liu, Xiubao Ren, Ningning Zhang.  (2025)  Fecal Microbiota Transplantation Alleviates Cirrhotic Portal Hypertension in Rats via Butyrate-Mediated HDAC3 Inhibition and PI3K/Akt/eNOS Signaling Regulation.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:40441587] [10.1016/j.ejphar.2025.177781]