Mitomycin C - 10mM in DMSO , CAS No.50-07-7

CAS: 50-07-7 Cat. No.: M407788 Formule: C₁₅H₁₈N₄O₅ Poids moléculaire: 334.33 Beilstein Registry Number: 7231816 Numéro CE: 200-008-6

GRADE & PURITY 10mM in DMSO

Synonyms

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs,FedEx DG Service

Vue d’ensemble

Information

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.
In vitro

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. ^[1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. ^[2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity.

In vivo

As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonymes

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs,FedEx DG Service

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Propriétés du produit

ALogP

-0.4

Noms et identifiants

Isomères SMILES

CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

WGK Allemagne

3

CAS alternatif

1404-00-8

Numéro ONU

2811

Groupe d'emballage

I

Poids moléculaire

334.33

Beilstein

7231816

Reaxy-Rn

630306

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=630306&ln=

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro Water: 97 mg/mL (200.25 mM); DMSO: Insoluble; Ethanol: Insoluble
• Sensibilité: Light & Heat & Moisture sensitive
• Indice de réfraction: 1.68 (Predicted)
• Point d'ébullition (°C): 581.8° C at 760 mmHg (Predicted)
• Point de fusion (°C): 64℃

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 50-07-7, the molecular formula is C15H18N4O5, and the molecular weight is 334.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.