MitoPQ - ≥98% , CAS No.1821370-28-8

CAS: 1821370-28-8 Cat. No.: M275666 Molecular Weight: 954.48 PubChem CID: 129909777

GRADE & PURITY ≥98%

Synonyms

MitoParaquat

Storage

Store at 2-8°C,Argon charged,Desiccated

Shipped In

Wet ice

Overview

MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study.

Specifications

Synonyms

MitoParaquat

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Selective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo . Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.

Storage

Store at 2-8°C, Argon charged, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
• IUPAC Name: 10-[4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]decyl-triphenylphosphanium;triiodide
• InChIKey: AOZZGHKENAZYTD-UHFFFAOYSA-K
• INCHI: 1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39;;;/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3;3*1H/q+3;;;/p-3
• Isomeric SMILES: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
• PubChem CID: 129909777
• Molecular Weight: 954.48

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in ethanol to 10 mM and in DMSO to 100 mM
• Sensitivity: Moisture sensitive.
• Molecular Weight: 954.500 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 15
• Exact Mass: 954.053 Da
• Monoisotopic Mass: 954.053 Da
• Topological Polar Surface Area: 7.800 Ų
• Heavy Atom Count: 45
• Formal Charge: 0
• Complexity: 646.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

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