MK6-83 - Moligand™, 10mM in DMSO , Activator of TRPML1;Activator of TRPML3, CAS No.1062271-24-2, Activator of TRPML1;Activator of TRPML3

CAS: 1062271-24-2 Cat. No.: M420493 Formule: C₁₆H₂₀N₂O₂S₂ Poids moléculaire: 336.47

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AKOS025147398 | MK683 | MK6-83 | 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide | 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)- | GTPL9783 | s6947 | NCGC00402264-04 | 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonymes

AKOS025147398 | MK683 | MK6-83 | 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide | 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)- | GTPL9783 | s6947 | NCGC00402264-04 | 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

TRPML channel activator (EC50= 110 nM). Also activates F408Δand F465L TRPML mutants (EC50values are 0.1 and 1.23μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.MK6-8

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ACTIVATOR

Mécanisme d'action

Activator of TRPML1;Activator of TRPML3

Noms et identifiants

• Pubchem Sid: 528765482
• Sourires canoniques: CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
• IUPAC Name: 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide
• InChIKey: IRGYSXZCDAWOOC-UHFFFAOYSA-N
• INCHI: 1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
• Isomères SMILES: CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
• Poids moléculaire: 336.47
• Reaxy-Rn: 41646062
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=41646062&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Piperidines
      • Subclass Phenylpiperidines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Piperidines
• Subclass: Phenylpiperidines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpiperidines
• Alternative Parents: Sulfanilides Dialkylarylamines Aniline and substituted anilines 2,5-disubstituted thiophenes Organosulfonamides Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylpiperidine - Sulfanilide - Tertiary aliphatic/aromatic amine - Aniline or substituted anilines - Dialkylarylamine - 2,5-disubstituted thiophene - Monocyclic benzene moiety - Organosulfonic acid amide - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Thiophene - Aminosulfonyl compound - Heteroaromatic compound - Tertiary amine - Azacycle - Organic nitrogen compound - Organic oxide - Amine - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organosulfur compound - Organic oxygen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

MCOLN1 Tchem Mucolipin-1 (2 Activities)

Discover Target: MCOLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Poids moléculaire: 336.500 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 336.097 Da
• Monoisotopic Mass: 336.097 Da
• Topological Polar Surface Area: 86.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 457.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1