≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
MKC-3946 MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.
Targets
IRE1α endoribonuclease
In vitro
MKC-3946 triggers modest growth inhibition in MM cell lines, without toxicity in normal mononuclear cells. Importantly, it significantly enhances cytotoxicity induced by bortezomib or 17-AAG, even in the presence of bone marrow stromal cells or exogenous IL-6. Both bortezomib and 17-AAG induce ER stress, evidenced by induction of XBP1s, which is blocked by MKC-3946. Apoptosis induced by these agents is enhanced by MKC-3946, associated with increased CHOP. MKC-3946 treatment does not inhibit IRE1α kinase function or binding of activated IRE1α to TRAF2 and downstream JNK signaling.
In vivo
MKC-3946 inhibits XBP1 splicing in a model of ER stress associated with significant growth inhibition of MM cells.
Cell Research(from reference)
Cell lines：RPMI 8226 cells
Concentrations：2.5, 5, 10 μM
Incubation Time：3 hours
| ALogP | 3.39 |
|---|---|
| hba_count | 2 |
| Nombre de HBD | 1 |
| Liaison rotative | 3 |
| Pubchem Sid | 504771755 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504771755 |
| Sourires canoniques | CN1CCN(CC1)C(=O)C2=CC=C(S2)C3=CC4=C(C=C3)C(=C(C=C4)O)C=O |
| IUPAC Name | 2-hydroxy-6-[5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl]naphthalene-1-carbaldehyde |
| InChIKey | IVQVBMWPWPTSNO-UHFFFAOYSA-N |
| INCHI | 1S/C21H20N2O3S/c1-22-8-10-23(11-9-22)21(26)20-7-6-19(27-20)15-2-4-16-14(12-15)3-5-18(25)17(16)13-24/h2-7,12-13,25H,8-11H2,1H3 |
| Isomères SMILES | CN1CCN(CC1)C(=O)C2=CC=C(S2)C3=CC4=C(C=C3)C(=C(C=C4)O)C=O |
| Poids moléculaire | 380.46 |
| Reaxy-Rn | 18798402 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18798402&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Classe | Naphthalenes |
| Subclass | Naphthols and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Naphthols and derivatives |
| Alternative Parents | Thiophene carboxamides 2-heteroaryl carboxamides N-methylpiperazines Aryl-aldehydes 2,5-disubstituted thiophenes 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Tertiary carboxylic acid amides Heteroaromatic compounds Trialkylamines Amino acids and derivatives Azacyclic compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 2-naphthol - 2-heteroaryl carboxamide - Thiophene carboxamide - Thiophene carboxylic acid or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Aryl-aldehyde - Phenol - N-methylpiperazine - 2,5-disubstituted thiophene - N-alkylpiperazine - 1,4-diazinane - Piperazine - Tertiary carboxylic acid amide - Thiophene - Heteroaromatic compound - Vinylogous acid - Tertiary amine - Tertiary aliphatic amine - Amino acid or derivatives - Carboxamide group - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Aldehyde - Organic oxygen compound - Organooxygen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Article |
|---|---|---|---|
 J2218229 | Certificate of Analysis | Aug 15, 2025 | M413961 |
| J2218228 | Certificate of Analysis | Aug 15, 2025 | M413961 |
| J2218227 | Certificate of Analysis | Aug 15, 2025 | M413961 |
| C2527341 | Certificate of Analysis | Jul 01, 2022 | M413961 |
| Solubilité | Solubility (25°C) In vitro DMSO: 38 mg/mL (99.87 mM); Ethanol: 3 mg/mL (7.88 mM); Water: Insoluble; |
|---|---|
| DMSO (mg/mL) Solubilité maximale | 38 |
| DMSO (mM) Solubilité maximale | 99.87909373 |
| Eau (mg/mL) Solubilité maximale | ＜1 |
| Poids moléculaire | 380.500 g/mol |
| XLogP3 | 3.800 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 380.119 Da |
| Monoisotopic Mass | 380.119 Da |
| Topological Polar Surface Area | 89.100 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 552.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
