ML204 hydrochloride - ≥99% , CAS No.2070015-10-8

CAS: 2070015-10-8 Cat. No.: M649192 Formule: C₁₅H₁₉ClN₂ Poids moléculaire: 262.78 PubChem CID: 49786978

GRADE & PURITY ≥99%

Synonyms

4-Methyl-2-(piperidin-1-yl)quinoline hydrochloride | ML204 HCl | AKOS032945007 | ML204 hydrochloride | ML 204 HCl; ML204 hydrochloride; ML 204 hydrochloride; ML-204 hydrochloride | MLS003227299 | BS-15926 | HY-12949A | ML204hydrochloride | 4-methyl-2-pipe

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Vue d’ensemble

ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels

In Vitro

ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca 2+ rise with an IC 50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. ML204 hydrochloride blocks TRPC4β activity induced through either G i/o stimulation by μ-opioid, 5HT 1A serotonin, and M 2 muscarinic receptors or G q/11 stimulation by the endogenous M 3 -like muscarinic receptors. ML204 hydrochloride blocks LPS-induced TRPC5 channel activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nonfasted male C57BL/6 (2-3 months)Dosage: 1 mg/kg Administration: Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) Result: Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.

Form:Solid

IC50& Target:TRPC4|TRPC5

Specifications

Synonymes

4-Methyl-2-(piperidin-1-yl)quinoline hydrochloride | ML204 HCl | AKOS032945007 | ML204 hydrochloride | ML 204 HCl; ML204 hydrochloride; ML 204 hydrochloride; ML-204 hydrochloride | MLS003227299 | BS-15926 | HY-12949A | ML204hydrochloride | 4-methyl-2-pipe

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels.

Conditions de stockage de stockage

Store at 2-8°C,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥99%

Noms et identifiants

Sourires canoniques

CC1=CC(=NC2=CC=CC=C12)N3CCCCC3.Cl

IUPAC Name

4-methyl-2-piperidin-1-ylquinoline;hydrochloride

InChIKey

QCABWRXQHZUBPW-UHFFFAOYSA-N

INCHI

1S/C15H18N2.ClH/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14;/h3-4,7-8,11H,2,5-6,9-10H2,1H3;1H

Isomères SMILES

CC1=CC(=NC2=CC=CC=C12)N3CCCCC3.Cl

CAS alternatif

2070015-10-8

PubChem CID

49786978

Termes d'entrée MeSH

ML 204;ML-204;ML204 cpd

Poids moléculaire

262.78

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives
      • Subclass Aminoquinolines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Aminoquinolines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Aminoquinolines and derivatives
• Alternative Parents: Dialkylarylamines Methylpyridines Aminopyridines and derivatives Piperidines Imidolactams Benzenoids Heteroaromatic compounds Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aminoquinoline - Dialkylarylamine - Aminopyridine - Methylpyridine - Piperidine - Pyridine - Imidolactam - Benzenoid - Heteroaromatic compound - Tertiary amine - Azacycle - Amine - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriétés chimiques et physiques

• Solubilité: H2O : ≥ 30 mg/mL (114.16 mM)
• Poids moléculaire: 262.780 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 262.124 Da
• Monoisotopic Mass: 262.124 Da
• Topological Polar Surface Area: 16.100 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 247.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Foire aux questions

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2070015-10-8, the molecular formula is C15H19ClN2, and the molecular weight is 262.78 g/mol. InChIKey QCABWRXQHZUBPW-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.