MT-1207 - Moligand™, 10 mM in DMSO , CAS No.1610794-70-1

CAS: 1610794-70-1 Cat. No.: M1498515 Formule: C₂₁H₂₅ClN₆S Poids moléculaire: 428.98

QUALITÉ & PURETÉ Moligand™, 10 mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

MT-1207 is an orally active and selective adrenergic α 1 and 5-HT 2A receptor antagonist. MT-1207 shows IC 50 <0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α 1A , α 1B , α 1D and 5-HT 2A , respectively. MT-1207 achieves an effective blood pressure (BP) reduction in the 2K2C rat model without damaging renal function. MT-1207 is a potent multitarget inhibitor with the potential for vasodilatation research.

Spécifications

Spécifications et pureté

Moligand™, 10 mM in DMSO

Conditions de stockage de stockage

Argon charged,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ANTAGONIST

Noms et identifiants

Poids moléculaire

428.98

Application Protocols

Item-specific facts

• No tested applications or protocols are provided for MT-1207 in the Product Data.

General protocol scaffold for small-molecule screening (non-item-specific)

• Stock solution: Prepare 10–50 mM in anhydrous DMSO under inert gas. Vortex and, if needed, sonicate briefly. Filter through 0.2 µm PTFE if particles persist.
• Aliquoting: Dispense single-use aliquots (10–50 µL) into inert-gas-purged vials or plates; freeze at −80 °C.
• Assay dilution: Thaw on ice; add to assay buffer to achieve final 0.1–1% DMSO v/v. Mix thoroughly to avoid localized precipitation.
• Controls: Include vehicle control, positive control (if available), and detergent control to assess aggregation artifacts.
• Data quality: Monitor compound stability by pre/post-assay LC–MS; confirm concentration by UV or quantitative NMR if needed.

Not specified for this item; refer to CoA/Spec Sheet

• Any vendor-validated application data, recommended concentrations, or positive control targets.

Biological Roles

Item-specific facts (from Product Data)

• No target, pathway, or mode-of-action information is provided for MT-1207.

General considerations (non-item-specific)

• As a small-molecule library member (Moligand™), MT-1207 may be used in discovery assays to explore potential interactions with enzymes, receptors, or protein–protein interfaces. Any biological role is empirical and assay-dependent until validated by orthogonal methods.
• Establish baseline properties important for biological testing: chemical stability in buffer, redox sensitivity, permeability (PAMPA/MDCK), and nonspecific binding (plasma protein, plasticware).
• Early risk flags to evaluate: pan-assay interference (PAINS) motifs, redox cyclers, metal chelation, and colloidal aggregation. Use established filters and counterscreens to contextualize activity.
• If hits are observed, characterize dose–response, kinetics, and reversibility; employ thermal shift assays, SPR, or CETSA to confirm target engagement.

Not specified for this item; refer to CoA/Spec Sheet

• Any claims about specific targets, pathways, or biological functions.

Buffer Applications

Applicability

• MT-1207 is a small-molecule library entry, not a buffering reagent. No acid/base constants or buffer-use instructions are provided.

Guidance (general)

• If formulating assay solutions, select buffer systems appropriate to your biology (e.g., phosphate, HEPES, MOPS) and confirm compound stability across the working pH and ionic strength.
• Monitor for precipitation upon dilution from DMSO into buffer; pre-mix with co-solvent or add slowly with mixing to avoid local supersaturation.

Not specified for this item; refer to CoA/Spec Sheet

• pKa values, buffering ranges, or any dedicated buffer formulations.

Green Alternatives

Context

• The core substance identity and solvent preferences for MT-1207 are not disclosed in this listing. Green considerations therefore focus on surrounding practices (solvents, processes) rather than the molecule itself.

Greener practice options (general guidance)

• Solvent choice hierarchy: Prefer water, ethanol, isopropanol, ethyl acetate, 2-MeTHF, CPME over chlorinated or high-toxicity solvents where assay/chemistry allows.
• Miniaturization: Use low-volume screening formats (384/1536-well) to minimize solvent and compound consumption.
• Energy: Keep cold-chain steps efficient—pre-chill equipment, plan aliquoting to reduce freezer door-open time, consolidate shipments.
• Inert atmosphere: Use glovebags or capped vials with septa to limit continuous inert gas flow.
• Waste: Segregate halogenated from non-halogenated waste; consider on-site solvent recycling for MeCN, MeOH, EtOH.

Comparison table (illustrative; non-item-specific)

• DMSO vs 2-pyrrolidone: DMSO has broad solvency and better toxicity profile; 2-pyrrolidone is less volatile but often harder to remove and may be more irritating.
• MeCN vs EtOH/H2O blends: MeCN is LC–MS friendly but toxic; EtOH/H2O is greener if the compound remains soluble and stable.

Note

• No greener structural analogs can be suggested without the compound’s structure. Apply green chemistry principles to the workflow surrounding MT-1207.

Pharmaceutical Uses

Scope

• No excipient status, pharmacopeial references, or formulation roles are provided for MT-1207. This product is supplied strictly for research use only.

General guidance (non-item-specific)

• In early discovery, similar small molecules may be evaluated for developability attributes (solubility, permeability, chemical/enzymatic stability) to inform lead optimization. Such work remains preclinical research and not for human or veterinary use.
• If used as an analytical reference standard in pharmaceutical R&D, ensure traceability: documented identity, purity, and stability with an auditable CoA.

Not specified for this item; refer to CoA/Spec Sheet

• Any status regarding GMP manufacturing, ICH stability data, or compendial compliance (USP/EP/JP).

Physical Properties

Item-specific facts (from Product Data)

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.

Not specified for this item; refer to CoA/Spec Sheet

• Molecular weight, molecular formula, melting point, boiling point, density, refractive index, pKa, logP/logD, solubility, UV/Vis characteristics, water/peroxide/metal content.

General/literature guidance (non-item-specific)

• For unknown small molecules supplied for screening, initial solubility scouting typically uses anhydrous DMSO (up to 10–50 mM stocks), then dilutions into assay media with co-solvent (0.1–1% DMSO) as needed.
• If the compound is moisture- or air-sensitive (suggested by argon charge), perform property measurements under inert atmosphere and use anhydrous solvents.
• Empirical solubility workflow: weigh micro-scale (0.5–2 mg) → test in DMSO, DMF, MeCN, EtOH, 1:1 MeCN/H2O, PBS, acetate/phosphate buffers across pH 5–8 → note clarity and stability over 24–48 h.
• Thermal behavior can be screened by DSC/TGA under nitrogen to understand stability windows prior to assay incubation.
• If light sensitivity is suspected, record spectra in amberware and minimize UV exposure during measurements.

Quality and Grades

Item-specific facts (from Product Data)

• Grade: Moligand™ (Aladdin Scientific)

What this implies (general explanation; not a specification)

• Moligand™ indicates a small-molecule ligand entry curated for discovery screening and chemical biology research. Such offerings are typically suitable for SAR campaigns, assay development, or library enrichment. Exact purity, residual solvent, identification tests, and analytical limits are not specified here—consult the CoA/Spec Sheet for this item.

Verification and QC considerations

• Identity confirmation: Request or review 1H/13C NMR, HRMS/LC–MS, and, when relevant, HPLC purity trace and water/volatile content (KF/GC). Ensure consistency with the referenced CAS (1610794-70-1).
• Batch-to-batch continuity: Library items can evolve; verify lot-specific data before critical experiments.
• Stabilizers/additives: Not specified for this item; refer to CoA/Spec Sheet. If present, account for them in bioassays and analytical quantitation.
• UV cutoffs/LC-MS compatibility: Not specified; evaluate background absorbance and ion suppression in your specific method.

Documentation

• For regulated workflows or exacting analytical needs, obtain the latest CoA, TDS, and SDS specific to the lot shipped.

Reaction and Applications

Item-specific facts (from Product Data)

• Category: Small molecules and compound libraries (小分子和化合物库).
• Manufacturer Applications: Not provided in the listing.

General applications for library molecules (non-item-specific)

• Screening and hit identification: Use in biochemical, biophysical (e.g., SPR, MST), or cell-based assays to identify modulators of targets of interest. Establish solubility, stability, and aggregation profile before screening.
• SAR exploration: Combine with analogs to map structure–activity relationships; track potency, selectivity, and physicochemical properties.
• Chemical probe development: If a tractable signal emerges, derivatize to append handles (biotin, photoaffinity groups) for target engagement studies.
• Analytical standards: With verified identity and purity, can serve as a reference standard in LC–MS method development.

Practical considerations

• Inert handling: Given argon charge and −80 °C storage, maintain anhydrous/inert conditions during weighing and solution prep.
• Stability testing: Run short-term stability in intended assay buffers and temperatures (e.g., 4–37 °C) and monitor by LC–MS to ensure integrity over assay time.
• Aggregation/artifacts: Evaluate with detergent controls, dynamic light scattering, or counterscreens to avoid false positives.

Note

• Specific reaction roles (e.g., as a reagent or building block) cannot be assigned without structure. Consult the CoA/Spec Sheet for functional group clues.

Reaction Conditions

Item-specific facts

• No reaction condition data, catalysts, or solvent guidance are provided for MT-1207.

General guidance (non-item-specific)

• For any chemical modifications or assay incubations, begin with small-scale trials. Use dry, degassed solvents and inert atmosphere if the compound is air/moisture sensitive (suggested by argon storage).
• Stability mapping: incubate at intended temperatures (e.g., 4, 25, 37 °C) and pH values, then analyze by LC–MS to confirm integrity over the desired timeframe.
• Typical stock preparation for screening: 10–50 mM in dry DMSO, aliquoted and stored at −20 to −80 °C under inert gas; avoid repeated freeze–thaw.
• If performing coupling or derivatization chemistry, select mild conditions first (e.g., room temperature, non-nucleophilic bases, short exposure) until functional group tolerance is known.

Not specified for this item; refer to CoA/Spec Sheet

• Any specific temperatures, times, catalysts, or yields.

Safety and Handling

Item-specific facts (from Product Data)

• Storage: Argon charged; Store at −80 °C.
• Shipping: Dry ice packs + Cold packs.
• GHS/Signal word/H-statements/Pictograms: Not specified for this item; refer to SDS.

Interpretation and practical handling (general guidance; defer to SDS for authoritative data)

• The combination of argon charge and −80 °C storage commonly indicates potential sensitivity to air, moisture, oxidation, and/or thermal degradation. Handle under inert atmosphere (nitrogen/argon) using glovebox or Schlenk techniques when practical.
• Avoid repeated freeze–thaw cycles; aliquot immediately upon first receipt while keeping material cold.
• Use standard PPE: lab coat, safety glasses, nitrile gloves. Work in a fume hood to avoid inhalation of dust/aerosols or solvent vapors.
• Incompatibilities to consider generally for air/moisture-sensitive organics: oxidizers, acids/bases (if hydrolytically labile), and protic solvents during weighing. Use dry apparatus and anhydrous solvents.
• First-aid overview (generic): if inhaled—move to fresh air; if on skin—wash with soap/water; if in eyes—rinse with water for several minutes; if ingested—rinse mouth. Seek medical attention and provide SDS.
• Waste: Collect in halogenated or non-halogenated organic waste depending on solvent system used; do not discharge to drains.
• Always consult the product-specific SDS for definitive hazard classification and emergency procedures.

Solvent Selection

Item-specific facts (from Product Data)

• No solvent preferences or solubility data are provided. Handle under inert atmosphere; store at −80 °C.

General strategy for small-molecule dissolution (non-item-specific)

• Primary stock solvent: anhydrous DMSO is usually the first-line solvent for screening compounds. Prepare 10–50 mM stocks if soluble. Filter if necessary (PTFE, 0.2 µm) under inert gas.
• Secondary options: DMF, NMP, acetonitrile, ethanol, methanol. For water-compatible work, co-solvent systems (e.g., 5–20% MeCN or 1–5% DMSO in buffer) are typical.
• Aqueous media: Test PBS, HEPES, or assay buffer across pH 6–8; consider cyclodextrin inclusion or surfactants (e.g., 0.01–0.1% Tween-20) if permitted by the assay.
• Air/moisture sensitivity: If the compound is hydrolytically or oxidatively labile, avoid protic solvents and aerated solutions; use dry, degassed solvents and work quickly at low temperature.

Comparison (general guidance)

• DMSO: highest solvating power for polar/apolar motifs; may affect biological assays above 0.5–1% v/v.
• MeCN: volatile, LC-MS friendly, good miscibility with water; lower solvating power for very lipophilic compounds.
• 2-MeTHF/CPME: greener, useful for synthetic steps; less relevant for aqueous bioassays.

Documentation

• Solubility for this item: Not specified; determine empirically and record lot-specific behavior.

Storage and Reconstitution

Item-specific facts (from Product Data)

• Storage Conditions: Argon charged; Store at −80 °C.
• Shipping: Dry ice packs + Cold packs.

Item-specific guidance

• Upon receipt: Keep package cold. Transfer immediately to a −80 °C freezer. Minimize time at ambient temperature.
• Aliquoting: Under inert atmosphere (glovebox or nitrogen/argon manifold), quickly aliquot into airtight vials. Purge headspace with argon before sealing.
• Reconstitution: Not specified for this item; refer to CoA/Spec Sheet. In general for small molecules, prepare concentrated stocks in anhydrous DMSO or another validated solvent based on solubility screening.

General best practices (non-item-specific)

• Avoid repeated freeze–thaw cycles: use single-use aliquots. Thaw on ice and keep solutions protected from air and, if suspected, from light (amber vials/foil wrap).
• Stability monitoring: Periodically check by LC–MS or HPLC for degradation during storage. Record lot, concentration, solvent, and preparation date on each aliquot.
• Disposal: Follow institutional guidelines for organic chemical waste; do not dispose to drain.

Not specified for this item; refer to CoA/Spec Sheet

• Exact solvent system, concentration limits, light sensitivity, shelf life, and retest date for this lot.

Structure and Identity

Item-specific facts (from Product Data)

• SKU: M1498515
• Product Name: MT-1207
• CAS: 1610794-70-1
• Grade: Moligand™
• Research Use: For research use only
• Storage condition provided for this item: Argon charged; Store at −80 °C
• Shipped on: Dry ice packs + Cold packs

Not specified for this item; refer to CoA/Spec Sheet

• Chemical name: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

General notes

• The CAS registry number uniquely identifies the substance independent of synonyms. Without a disclosed structure, stereochemistry, and functional groups cannot be described.
• Argon packaging and deep-cold storage commonly indicate sensitivity to air, moisture, oxidation, or thermal degradation; handle accordingly (see Safety & Handling).

Synthetic Utility

Item-specific constraints

• The structure, functional groups, and reactivity of MT-1207 are not disclosed in this listing; therefore, specific transformations or named-reaction roles cannot be provided.

General possibilities for library molecules (non-item-specific)

• If the structure becomes available and contains common handles (e.g., aryl halides, boronates, amines, acids), it may be elaborated via cross-coupling (Suzuki, Buchwald–Hartwig), amide coupling, or reductive amination to generate analogs for SAR.
• If heterocycles are present, late-stage C–H functionalization or N-oxide strategies may enable diversification without de novo synthesis.
• Analytical leverage: Even without using the molecule as a reagent, it can serve as an internal/response standard where appropriate after validation.

Action items

• Consult the CoA/Spec Sheet or request structural disclosure under CDA if you intend synthetic derivatization. Validate stability under the intended reaction conditions before scale-up.

Target Specificity

Item-specific facts

• No target, epitope, or binding specificity information is provided for MT-1207.

Statement of applicability

• This section is typically relevant for biologics or validated chemical probes with known targets. For this Moligand™ library entry, target specificity is not established in the Product Data.

Not specified for this item; refer to CoA/Spec Sheet

• Any claims of target class, selectivity profiles, or binding constants.

Foire aux questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1610794-70-1, the molecular formula is C21H25ClN6S, and the molecular weight is 428.98 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.