MTS Reagent - ≥95%(HPLC) , CAS No.138169-43-4

CAS: 138169-43-4 Cat. No.: M275698 Formule: C₂₀H₁₇N₅O₆S₂ Poids moléculaire: 487.515

GRADE & PURITY ≥95%(HPLC)

Synonyms

5-[3-(carboxymethoxy)phenyl]-2-(4,5-dimethyl-1,3-thiazol-2-yl)-3-(4-sulfonatophenyl)-3H-1,2,3,4-tetrazol-2-ylium | FT-0629025 | 5-[3-(Carboxymethoxy)phenyl]-3-(4,5-dimethyl-2-thiazolyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt | 3-(4,5-Dimethylthiazol-

Storage

Store at 2-8°C,Protected from light,Argon charged,Desiccated

Shipped In

Wet ice

Vue d’ensemble

MTS reagent is one of the most common water-soluble tetrazolium reagents that are widely used to quantify cell viability by absorption spectrophotometry. A variety of tetrazolium inner salts are used for determining cell viability in proliferation assays by monitoring their color changes. Metabolically active cells reduce colorless tetrazolium inner salts into the colored formazan products that might be either soluble or insoluble in cell culture media depending on the structures of tetrazolium reagents. The conversion of tetrazolium inner salts to formazans is thought to be carried out by NAD(P)H-dependent dehydrogenase enzymes.

Application：

Cell Viability Assay; Cell Proliferation Assay; Cytotoxicity Assay

Specifications

Synonymes

5-[3-(carboxymethoxy)phenyl]-2-(4,5-dimethyl-1,3-thiazol-2-yl)-3-(4-sulfonatophenyl)-3H-1,2,3,4-tetrazol-2-ylium | FT-0629025 | 5-[3-(Carboxymethoxy)phenyl]-3-(4,5-dimethyl-2-thiazolyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt | 3-(4,5-Dimethylthiazol-

Spécifications et pureté

≥95%(HPLC)

Stabilité et stockage

Store at 2-8℃ long term (1 year).Store in the dark. Desiccated. Under Inert Atmosphere.

Conditions de stockage de stockage

Store at 2-8°C,Protected from light,Argon charged,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥95%(HPLC)

Noms et identifiants

• Sourires canoniques: CC1=C(SC(=N1)[N+]2=NC(=NN2C3=CC=C(C=C3)S(=O)(=O)[O-])C4=CC(=CC=C4)OCC(=O)O)C
• IUPAC Name: 4-[5-[3-(carboxymethoxy)phenyl]-3-(4,5-dimethyl-1,3-thiazol-2-yl)tetrazol-3-ium-2-yl]benzenesulfonate
• InChIKey: APRZHQXAAWPYHS-UHFFFAOYSA-N
• INCHI: 1S/C20H17N5O6S2/c1-12-13(2)32-20(21-12)25-23-19(14-4-3-5-16(10-14)31-11-18(26)27)22-24(25)15-6-8-17(9-7-15)33(28,29)30/h3-10H,11H2,1-2H3,(H-,26,27,28,29,30)
• Isomères SMILES: CC1=C(SC(=N1)[N+]2=NC(=NN2C3=CC=C(C=C3)S(=O)(=O)[O-])C4=CC(=CC=C4)OCC(=O)O)C
• Poids moléculaire: 487.515
• Reaxy-Rn: 24181324
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24181324&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Tetrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Tetrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenyltetrazoles and derivatives
• Alternative Parents: Phenoxyacetic acid derivatives Benzenesulfonic acids and derivatives 1-sulfo,2-unsubstituted aromatic compounds Benzenesulfonyl compounds Phenoxy compounds Phenol ethers 2,4,5-trisubstituted thiazoles Alkyl aryl ethers Sulfonyls Organosulfonic acids Heteroaromatic compounds Carboxylic acids Azacyclic compounds Monocarboxylic acids and derivatives Organopnictogen compounds Carbonyl compounds Organic zwitterions Organonitrogen compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenoxyacetate - Phenyltetrazole - Benzenesulfonate - Arylsulfonic acid or derivatives - Benzenesulfonyl group - 1-sulfo,2-unsubstituted aromatic compound - 2,4,5-trisubstituted 1,3-thiazole - Phenoxy compound - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Organic sulfonic acid or derivatives - Thiazole - Sulfonyl - Organosulfonic acid - Heteroaromatic compound - Organosulfonic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Ether - Monocarboxylic acid or derivatives - Azacycle - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organooxygen compound - Organosulfur compound - Hydrocarbon derivative - Organic oxide - Organic zwitterion - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenyltetrazoles and derivatives. These are compounds containing a phenyltetrazole skeleton, which consists of a tetrazole bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriétés chimiques et physiques

• Solubilité: Soluble in water.
• Poids moléculaire: 487.500 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 6
• Exact Mass: 487.062 Da
• Monoisotopic Mass: 487.062 Da
• Topological Polar Surface Area: 188.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 777.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Références

1. Kehua Wang, Ling Wang, Zhuye Shang, Xingzhi Yang, Hongmei Li, Xiaochun Wang, Mingchang Zhu, Qingtao Meng.  (2024)  A series of DNA targeted Cu (II) complexes containing 1,8-naphthalimide ligands: Synthesis, characterization and in vitro anticancer activity.  JOURNAL OF INORGANIC BIOCHEMISTRY,      [PMID:39236444] [10.1016/j.jinorgbio.2024.112721]

2. Yujie Zhu, Chenchen Song, Dongdong Yao, Fangyu Qiao, Yang Zou, Yonggang Lv.  (2025)  Liquid Metal-Based Conductive Nerve Guidance Conduit Combined With Electrical Stimulation Boosts Peripheral Nerve Repair.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  113  (2): (e37880).  [PMID:39893555] [10.1002/jbm.a.37880]

3. Yuan Tian, Yunjia Song, Jialin Liu, Suli Lan, Bo Chen, Ying Li, Jianmin Han.  (2024)  Nanoparticle-mediated photothermal and photodynamic antibacterial therapy for the treatment of periodontitis.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2024.135988]

4. Hongqiang Li, Chenglong Liu, Zhaokai Peng, Qian Chen, Richard M. Kasomo, Yanfeng Jin, Xiaoqing Weng, Nelima M. Ondiaka, Yingxin Chen, Shaoxian Song.  (2024)  Utilization of methyltrichlorosilane as a novel and efficient reagent to enhance fluorine recovery from wet-process phosphoric acid.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2024.141295]