MTX-23 , CAS No.2488296-74-6

CAS: 2488296-74-6 Cat. No.: M649194 Formule: C₄₃H₅₃F₂N₇O₇S₂ Poids moléculaire: 882.05

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Vue d’ensemble

MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.

In Vitro

MTX-23 (compound 16; 0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner. MTX-23 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels. MTX-23 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: 22Rvl cells Concentration: 0-20 μM Incubation Time: 4 days Result: Reduced the cell count by less than 50 percent. Apoptosis AnalysisCell Line: 22Rvl cells Concentration: 1 μM Incubation Time: 0-48 h Result: Induced cell apoptosis in 22Rvl cells. Western Blot AnalysisCell Line: 22Rvl cells Concentration: 10 μM Incubation Time: 4 days Result: Reduced AR-V7 protein levels.

In Vivo

MTX-23 (compound 16; 2.5 mg/mL; intratumor injection) inhibits tumor growth in nu/nu mice with 22Rvl-Enz R tumor xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: nu/nu mice with 22Rvl-Enz R tumor xenografts Dosage: 2.5 mg/mL Administration: intratumor injection Result: Inhibited tumor growth in nu/nu mice with 22Rvl-Enz R tumor xenografts.

Form:Solid

Specifications

Mécanismes biochimiques et physiologiques

MTX-23 is an AR-based PROTAC . MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Noms et identifiants

• Poids moléculaire: 882.05

Foire aux questions

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2488296-74-6, the molecular formula is C43H53F2N7O7S2, and the molecular weight is 882.05 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.